[HTML][HTML] Neutralizing monoclonal antibodies for treatment of COVID-19

PC Taylor, AC Adams, MM Hufford… - Nature Reviews …, 2021 - nature.com
Several neutralizing monoclonal antibodies (mAbs) to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) have been developed and are now under evaluation in clinical …

Prevention and treatment strategies for respiratory syncytial virus (RSV)

D Gatt, I Martin, R AlFouzan, TJ Moraes - Pathogens, 2023 - mdpi.com
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract
disease, especially in young children. Despite its global impact on healthcare, related to its …

Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract

H Wu, DS Pfarr, S Johnson, YA Brewah… - Journal of molecular …, 2007 - Elsevier
Respiratory syncytial virus (RSV) is the leading cause of viral bronchiolitis and pneumonia in
infants and children. Currently, palivizumab is the only approved monoclonal antibody …

Product review on the monoclonal antibody palivizumab for prevention of respiratory syncytial virus infection

B Resch - Human vaccines & immunotherapeutics, 2017 - Taylor & Francis
Respiratory syncytial virus (RSV) accounts for about 20% of all respiratory infections in
children below the age of 5 y. It is associated with up to 63% of all acute respiratory …

Palivizumab prophylaxis, respiratory syncytial virus, and subsequent recurrent wheezing

EAF Simoes, JR Groothuis, X Carbonell-Estrany… - The Journal of …, 2007 - Elsevier
OBJECTIVE: Children who experience respiratory syncytial virus (RSV) lower respiratory
tract infections (LRTIs) early in life have high rates of subsequent recurrent wheezing …

Respiratory syncytial virus infection in older adults: an under-recognized problem

AR Branche, AR Falsey - Drugs & aging, 2015 - Springer
Human respiratory syncytial virus (RSV) is an enveloped, single-stranded, negative-sense
RNA virus and member of the Paramyxoviridae family of the genus Pneumovirus that was …

Respiratory syncytial virus: current and emerging treatment options

TL Turner, BT Kopp, G Paul, LC Landgrave… - ClinicoEconomics …, 2014 - Taylor & Francis
Respiratory syncytial virus (RSV) is an important respiratory pathogen in infants and children
worldwide. Although RSV typically causes mild upper respiratory infections, it frequently …

Current state and challenges in respiratory syncytial virus drug discovery and development

G Zou, S Cao, Z Gao, J Yie, JZ Wu - Antiviral Research, 2024 - Elsevier
Human respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract
infections (LRTI) in young children and elderly people worldwide. Recent significant …

Monoclonal antibody-induced cytokine-release syndrome

PJ Bugelski, R Achuthanandam… - Expert review of …, 2009 - Taylor & Francis
Monoclonal antibodies (mAbs) are widely used in anti-inflammatory and tumor therapy.
Although effective, mAbs can cause a variety of adverse effects. An important toxicity seen …

Population pharmacokinetics of palivizumab, a humanized anti-respiratory syncytial virus monoclonal antibody, in adults and children

GJ Robbie, L Zhao, J Mondick… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Although it has been on the market for over a decade, confusion remains regarding the
pharmacokinetics (PK) and optimal dosing of palivizumab, a humanized IgG1κ monoclonal …