Inflammation in obesity, diabetes, and related disorders

TV Rohm, DT Meier, JM Olefsky, MY Donath - Immunity, 2022 - cell.com
Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Adipose-tissue plasticity in health and disease

A Sakers, MK De Siqueira, P Seale, CJ Villanueva - Cell, 2022 - cell.com
Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

A global view of the interplay between non-alcoholic fatty liver disease and diabetes

N Stefan, K Cusi - The lancet Diabetes & endocrinology, 2022 - thelancet.com
Non-alcoholic fatty liver disease (NAFLD) has become an epidemic, much like other non-
communicable diseases (NCDs), such as cancer, obesity, diabetes, and cardiovascular …

Why does obesity cause diabetes?

S Klein, A Gastaldelli, H Yki-Järvinen, PE Scherer - Cell metabolism, 2022 - cell.com
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …

Obesity, inflammation, and immune system in osteoarthritis

U Nedunchezhiyan, I Varughese, ARJ Sun… - Frontiers in …, 2022 - frontiersin.org
Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

Obesity and the risk of cardiometabolic diseases

PL Valenzuela, P Carrera-Bastos… - Nature reviews …, 2023 - nature.com
The prevalence of obesity has reached pandemic proportions, and now approximately 25%
of adults in Westernized countries have obesity. Recognized as a major health concern …

Obesity phenotypes, diabetes, and cardiovascular diseases

ME Piché, A Tchernof, JP Després - Circulation research, 2020 - Am Heart Assoc
This review addresses the interplay between obesity, type 2 diabetes mellitus, and
cardiovascular diseases. It is proposed that obesity, generally defined by an excess of body …

[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Adipose tissue at single-cell resolution

B Maniyadath, Q Zhang, RK Gupta, S Mandrup - Cell metabolism, 2023 - cell.com
Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

[HTML][HTML] The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities

H Steinbrenner, LH Duntas, MP Rayman - Redox biology, 2022 - Elsevier
This review addresses the role of the essential trace element, selenium, in type-2 diabetes
mellitus (T2DM) and its metabolic co-morbidities, ie, metabolic syndrome, obesity and non …