Origins of specificity in protein-DNA recognition
Specific interactions between proteins and DNA are fundamental to many biological
processes. In this review, we provide a revised view of protein-DNA interactions that …
processes. In this review, we provide a revised view of protein-DNA interactions that …
Multivalent engagement of chromatin modifications by linked binding modules
Various chemical modifications on histones and regions of associated DNA play crucial
roles in genome management by binding specific factors that, in turn, serve to alter the …
roles in genome management by binding specific factors that, in turn, serve to alter the …
Verification of protein structures: patterns of nonbonded atomic interactions
A novel method for differentiating between correctly and incorrectly determined regions of
protein structures based on characteristic atomic interactions is described. Different types of …
protein structures based on characteristic atomic interactions is described. Different types of …
Assessment of protein models with three-dimensional profiles
AS methods for determining protein three-dimensional (3D) structure develop, a continuing
problem is how to verify that the final protein model is correct. The revision of several protein …
problem is how to verify that the final protein model is correct. The revision of several protein …
Highlights of the DNA cutters: a short history of the restriction enzymes
WAM Loenen, DTF Dryden, EA Raleigh… - Nucleic acids …, 2014 - academic.oup.com
Abstract In the early 1950's,'host-controlled variation in bacterial viruses' was reported as a
non-hereditary phenomenon: one cycle of viral growth on certain bacterial hosts affected the …
non-hereditary phenomenon: one cycle of viral growth on certain bacterial hosts affected the …
Recent advances in zinc enzymology
WN Lipscomb, N Sträter - Chemical Reviews, 1996 - ACS Publications
Posters and lectures presented at the Seventh International Conference on Bioinorganic
Chemistry (ICBIC) in Lubeck, Germany, last year was divided into 16 sections, including …
Chemistry (ICBIC) in Lubeck, Germany, last year was divided into 16 sections, including …
Coupling of local folding to site-specific binding of proteins to DNA
RS Spolar, MT Record Jr - Science, 1994 - science.org
Thermodynamic studies have demonstrated the central importance of a large negative heat
capacity change (Δ C° assoc) in site-specific protein-DNA recognition. Dissection of the …
capacity change (Δ C° assoc) in site-specific protein-DNA recognition. Dissection of the …
An overview of the structures of protein-DNA complexes
On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein
Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different …
Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different …
Hhal methyltransferase flips its target base out of the DNA helix
S Klimasauskas, S Kumar, RJ Roberts, X Cheng - Cell, 1994 - cell.com
The crystal structure has been determined at 2.8 A resolution for a chemically-trapped
covalent reaction intermediate between the Hhal DNA cytosine-lmethyltransferase, S …
covalent reaction intermediate between the Hhal DNA cytosine-lmethyltransferase, S …
Structure and function of type II restriction endonucleases
A Pingoud, A Jeltsch - Nucleic acids research, 2001 - academic.oup.com
More than 3000 type II restriction endonucleases have been discovered. They recognize
short, usually palindromic, sequences of 4–8 bp and, in the presence of Mg2+, cleave the …
short, usually palindromic, sequences of 4–8 bp and, in the presence of Mg2+, cleave the …