The cytotoxicity and tumor-targeting properties of the anti-HER2/neu monoclonal antibody
trastuzumab modified with peptides (CGYG PKKKRKV GG) harboring the nuclear …

Intracellular trafficking of Auger electron emitting radionuclides to perinuclear and nuclear
regions of cells is critical to realizing their full therapeutic potential. In the present study …

In previous experiments, 125I-labeled 1F5 (anti-CD20) was found to kill B-lymphoma cells
efficiently and specifically. Unexpectedly, the number of antibody (Ab) molecules taken up …

Monoclonal antibodies (mAbs) labeled with α-emitting radionuclides such as 211At, 212Bi,
213Bi, and 212Pb (which decays by β-emission to its α-emitting daughter, 212Bi) are being …

Targeting of tumor cells with radiolabeled biomolecules is a possible approach to inactivate
disseminated tumor cells. However, rapid degradation of the biomolecules after cellular …

Tissue factor (TF) is a type I transmembrane protein and the initiator of the extrinsic blood
coagulation pathway. TF plays a critical role in tumor development and its overexpression is …

Abstract<? Pub Inc> Monoclonal antibodies (mAbs) conjugated to nuclear localization
sequences (NLS) and labeled with Auger electron-emitters have great potential for targeted …

Characterising the mechanisms underpinning caspase-independent programmed cell death
(CI-PCD) induction by uncross-linked rituximab in B-cells may positively impact upon the …

Block copolymer micelles have emerged as a viable formulation strategy with several drugs
relying on this technology in clinical evaluation. To date, information on the tumor …

Objective: The cytotoxic property of anti-EGFR-1 monoclonal-antibody nimotuzumab
modified with nuclear localization sequence and radiolabeled with 111In was evaluated in …