Abstract According to the World Health Organization (WHO), depression is a common
mental disorder and includes complex interaction between social and psychological …

This article purposes to provide insights to piperazine based molecular designs that will
facilitate drug discovery program in future. In our pursuit to summarize the reservoir of …

In the current work, a hybridisation strategy was adopted between the privileged building
blocks, benzofuran and piperazine, with the aim of designing novel CDK2 type II inhibitors …

Carbon dioxide (CO 2) considerably contributes to the greenhouse effects and
consequently, to the global warming. Thus, reduction of CO 2 emissions/concentration in the …

The β-carboline skeleton is prevalent in a vast collection of naturally present alkaloids. Most
of these alkaloids and their derivatives have been found to show significant biological …

Thiosemicarbazones (TSCs) are an interesting class of ligands that show a diverse range of
biological activity, including anti-fungal, anti-viral and anti-cancer effects. Our previous …

Abstract A series of imidazo [1, 2-a] pyrimidine Mannich bases were designed, synthesized
in two phases. Mannich bases were obtained by one pot three component condensation of …

Abstract A series of 3-[(4-substitutedpiperazin-1-yl) methyl]-1H-indole derivatives were
synthesized, and their structures were confirmed by spectral analysis. All the compounds …

The piperazine ring system is among the medicinally important nitrogen-containing
heterocyclic ring systems and is exploited for the synthesis of various drug molecules. A …

In this paper, a series of podophyllotoxin piperazine acetate ester derivatives were
synthesized and investigated due to their antiproliferation activity on different human cancer …