Significance: The remarkable geometry of the axon exposes it to unique challenges for
survival and maintenance. Axonal degeneration is a feature of peripheral neuropathies …

There is a myriad of enzymes within the body responsible for maintaining homeostasis by
providing the means to convert substrates to products as and when required. Physiological …

Depletion of nicotinamide adenine dinucleotide (NAD+) is associated with aging and
disease, spurring the study of dietary supplements to replenish NAD+. The catabolism of …

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in NAD+
biosynthesis via salvage of NAM formed from catabolism of NAD+ by proteins with NADase …

Evidence supports boosting nicotinamide adenine dinucleotide (NAD+) to counteract
oxidative stress in aging and neurodegenerative disease. One approach is to enhance the …

Nicotinamide phosphoribosyltransferase (NAMPT) is a key rate-limiting enzyme in the
nicotinamide adenine dinucleotide (NAD+) salvage pathway, primarily catalyzing the …

The cofactor nicotinamide adenine dinucleotide (NAD+) plays a key role in a wide range of
physiological processes and maintaining or enhancing NAD+ levels is an established …

As the aging population continues to grow rapidly, age-related diseases are becoming an
increasing burden on the healthcare system and a major concern for the well-being of …

Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the
nicotinamide adenine dinucleotide (NAD) salvage pathway in mammals. It is of great …

Age-related macular degeneration (AMD) is a leading cause of legal blindness and
moderate and severe vision impairment (MSVI) in people older than 50 years. It is classified …