Applications in high-content functional protein microarrays

CD Moore, OZ Ajala, H Zhu - Current opinion in chemical biology, 2016 - Elsevier
Highlights•Human proteome microarrays have been developed.•Unbiased, high-throughput
platform for discovery-oriented biology.•Useful for characterization of protein binding …

Toward a systems-level view of dynamic phosphorylation networks

RH Newman, J Zhang, H Zhu - Frontiers in genetics, 2014 - frontiersin.org
To better understand how cells sense and respond to their environment, it is important to
understand the organization and regulation of the phosphorylation networks that underlie …

Protein microarray applications: autoantibody detection and posttranslational modification

A Atak, S Mukherjee, R Jain, S Gupta, VA Singh… - …, 2016 - Wiley Online Library
The discovery of DNA microarrays was a major milestone in genomics; however, it could not
adequately predict the structure or dynamics of underlying protein entities, which are the …

Proteome-wide tyrosine phosphorylation analysis reveals dysregulated signaling pathways in ovarian tumors*[S]

G Song, L Chen, B Zhang, Q Song, Y Yu… - Molecular & Cellular …, 2019 - ASBMB
The recent accomplishment of comprehensive proteogenomic analysis of high-grade serous
ovarian carcinoma (HGSOC) tissues reveals cancer associated molecular alterations were …

Discovering cancer biomarkers from clinical samples by protein microarrays

B Hu, X Niu, L Cheng, LN Yang, Q Li… - PROTEOMICS …, 2015 - Wiley Online Library
Cancer biomarkers are of potential use in early cancer diagnosis, anticancer therapy
development, and monitoring the responses to treatments. Protein‐based cancer …

[PDF][PDF] USP8/UBPy-regulated sorting and the development of sperm acrosome: the recruitment of MET

G Berruti, C Paiardi - Reproduction, 2015 - academia.edu
The acrosome is a peculiar vacuole that at fertilization undergoes the acrosome reaction
(AR), an event unique in the sperm life. Contents released promote sperm penetration …

Analysis of KLF4 regulated genes in cancer cells reveals a role of DNA methylation in promoter-enhancer interactions

O Oyinlade, S Wei, K Kammers, S Liu, S Wang, D Ma… - Epigenetics, 2018 - Taylor & Francis
Recent studies have revealed an unexpected role of DNA methylation at promoter regions in
transcription activation. However, whether DNA methylation at enhancer regions activates …

Krüppel-like factor 9 and histone deacetylase inhibitors synergistically induce cell death in glioblastoma stem-like cells

B Tung, D Ma, S Wang, O Oyinlade, J Laterra, M Ying… - BMC cancer, 2018 - Springer
Background The dismal prognosis of patients with glioblastoma (GBM) is attributed to a rare
subset of cancer stem cells that display characteristics of tumor initiation, growth, and …

A human proteome array approach to identifying key host proteins targeted by Toxoplasma kinase ROP18

Z Yang, Y Hou, T Hao, HS Rho, J Wan, Y Luan… - Molecular & Cellular …, 2017 - ASBMB
Toxoplasma kinase ROP18 is a key molecule responsible for the virulence of Toxoplasma
gondii; however, the mechanisms by which ROP18 exerts parasite virulence via interaction …

Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage

P Saha, G Saraswat, P Chakraborty… - …, 2012 - rep.bioscientifica.com
The tubers of Pueraria tuberosa have folkloric repute as emmenagogue. The n-BuOH
fraction of the ethanolic extract of tubers exhibits significant antifertility activity in laboratory …