Advances in mass spectrometry to unravel the structure and function of protein condensates
Membrane-less organelles assemble through liquid–liquid phase separation (LLPS) of
partially disordered proteins into highly specialized microenvironments. Currently, it is …
partially disordered proteins into highly specialized microenvironments. Currently, it is …
Biomolecular condensates and disease pathogenesis
Biomolecular condensates or membraneless organelles (MLOs) formed by liquid-liquid
phase separation (LLPS) divide intracellular spaces into discrete compartments for specific …
phase separation (LLPS) divide intracellular spaces into discrete compartments for specific …
HDX–MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker
R Chen, H Glauninger, DN Kahan… - Proceedings of the …, 2024 - National Acad Sciences
Eukaryotic cells form condensates to sense and adapt to their environment [SF Banani, HO
Lee, AA Hyman, MK Rosen, Nat. Rev. Mol. Cell Biol. 18, 285–298 (2017), H. Yoo, C …
Lee, AA Hyman, MK Rosen, Nat. Rev. Mol. Cell Biol. 18, 285–298 (2017), H. Yoo, C …
Liquid–liquid phase separation primes spider silk proteins for fiber formation via a conditional sticker domain
Many protein condensates can convert to fibrillar aggregates, but the underlying
mechanisms are unclear. Liquid–liquid phase separation (LLPS) of spider silk proteins …
mechanisms are unclear. Liquid–liquid phase separation (LLPS) of spider silk proteins …
Ion Mobility mass spectrometry unveils global protein conformations in response to conditions that promote and reverse liquid–liquid phase separation
Liquid–liquid phase separation (LLPS) is a process by which biomacromolecules,
particularly proteins, condense into a dense phase that resembles liquid droplets …
particularly proteins, condense into a dense phase that resembles liquid droplets …
Liquid-liquid phase separation in human diseases: Functions, mechanisms and treatments
T Yue, F Zhang, Y Wei, Z Wang - Nano Today, 2024 - Elsevier
Cells are separated into functional regions by non-membrane organelles and membrane-
enclosed organelles, ensuring that various cellular activities occur in a controlled manner in …
enclosed organelles, ensuring that various cellular activities occur in a controlled manner in …
Liquid-liquid Phase Separation in Aging: Novel Insights in the Pathogenesis and Therapeutics
H Wang, J Tang, S Yan, C Li, Z Li, Z Xiong, Z Li… - Ageing Research …, 2024 - Elsevier
The intricate organization of distinct cellular compartments is paramount for the maintenance
of normal biological functions and the orchestration of complex biochemical reactions …
of normal biological functions and the orchestration of complex biochemical reactions …
Emerging experimental methods to study the thermodynamics of biomolecular condensate formation
The formation of biomolecular condensates in vivo is increasingly recognized to underlie a
multitude of crucial cellular functions. Furthermore, the evolution of highly dynamic protein …
multitude of crucial cellular functions. Furthermore, the evolution of highly dynamic protein …
Phase separation in DNA double-strand break response
HL Liu, H Nan, WW Zhao, XB Wan, XJ Fan - Nucleus, 2024 - Taylor & Francis
ABSTRACT DNA double-strand break (DSB) is the most dangerous type of DNA damage,
which may lead to cell death or oncogenic mutations. Homologous recombination (HR) and …
which may lead to cell death or oncogenic mutations. Homologous recombination (HR) and …
Major structural protein in locust mandible capable of forming extraordinarily stiff materials via hierarchical self-assembly
H Qi, Y Teng, S Chen, F Yuan, L Chen, X Liang… - Matter, 2024 - cell.com
Locust mandibles have stiff cuticles to process rough food. Therefore, the mandible is a
reservoir of stiff structural proteins (SPs). Here, LmCPH-1, the most abundant SP in locust …
reservoir of stiff structural proteins (SPs). Here, LmCPH-1, the most abundant SP in locust …