The central nervous system (CNS) receives information from afferent neurons, circulating
hormones, and absorbed nutrients and integrates this information to orchestrate the actions …

Prior mouse genetic research has set the stage for a deep understanding of appetite
regulation. This goal is now being realized through the use of recent technological …

The most successful obesity therapeutics, glucagon-like peptide-1 receptor (GLP1R)
agonists, cause aversive responses such as nausea and vomiting,, effects that may …

The nervous system uses various coding strategies to process sensory inputs. For example,
the olfactory system uses large receptor repertoires and is wired to recognize diverse …

Energy homeostasis requires precise measurement of the quantity and quality of ingested
food. The vagus nerve innervates the gut and can detect diverse interoceptive cues, but the …

After ingestion of toxin-contaminated food, the brain initiates a series of defensive responses
(eg, nausea, retching, and vomiting). How the brain detects ingested toxin and coordinates …

During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Systemic metabolism has to be constantly adjusted to the variance of food intake and even
be prepared for anticipated changes in nutrient availability. Therefore, the brain integrates …

Sensory neurons relay gut-derived signals to the brain, yet the molecular and functional
organization of distinct populations remains unclear. Here, we employed intersectional …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …