Abstract Nearly 100 years ago, Ivan Pavlov demonstrated that dogs could learn to use a
neutral cue to predict a biologically relevant event: after repeated predictive pairings …

Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …

Importance There is a paucity of controlled treatment trials for the treatment of conversion
disorder, seizures type, also known as psychogenic nonepileptic seizures (PNES) …

Importance Whether and under which conditions D-cycloserine (DCS) augments the effects
of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and …

Anxiety is the most prevalent psychiatric problem of our time. Decades of research have
gone into probing its mysteries and developing treatments. But what if we've been thinking …

Despite the exponential increase in fear research during the last years, few studies have
included female subjects in their design. The need to include females arises from the …

Brain-derived neurotrophic factor (BDNF) and its single transmembrane receptor,
tropomysin-related kinase B (TrkB), are essential for adult synaptic plasticity and the …

JNJ-42165279 is a selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme
responsible for the degradation of fatty acid amides (FAA) including anandamide (AEA) …

This review describes the latest developments in our understanding of how the serotonergic
system modulates Pavlovian fear conditioning, fear expression and fear extinction. These …

There is considerable interest, from both a basic and clinical standpoint, in gaining a greater
understanding of how pharmaceutical or behavioral manipulations alter fear extinction in …