Familial hypercholesterolemia (FH) is characterized by raised serum LDL cholesterol levels,
which result in excess deposition of cholesterol in tissues, leading to accelerated …

Women live longer than men and develop cardiovascular disease (CVD) at an older age.
The metabolic syndrome represents a major risk factor for the development of CVD, and …

Atualmente sabemos que é possível obter uma redução na incidência de complicações da
aterosclerose com a adoção de um estilo de vida saudável e com o tratamento …

Familial hypercholesterolemia (FH) is a common genetic cause of elevated low-density
lipoprotein cholesterol (LDL-C) due to defective clearance of circulating LDL particles. All FH …

Background Although familial hypercholesterolemia (FH) is a severe monogenic disease, it
has been shown that clinical risk factors and common genetic variants can modify …

OBJECTIVE: To determine the spectrum of gene mutations and the genotype–phenotype
correlations in patients with Autosomal Dominant Hypercholesterolemia (ADH) identified in …

Polygenic diseases, which are genetic disorders caused by the combined action of multiple
genes, pose unique and significant challenges for the diagnosis and management of …

High-density lipoproteins cholesterol (HDL-C) level, a strong coronary artery disease (CAD)
clinical biomarker, shows significant interindividual variability. However, the molecular …

Rheumatoid arthritis (RA) associates with excess cardiovascular morbidity and mortality,
resulting in significantly shortened lifespan. Traditional risk factors (eg dyslipidaemia and …

▪ Abstract Cholesterol and its metabolites play a variety of essential roles in living systems.
Virtually all animal cells require cholesterol, which they acquire through synthesis or uptake …