The gut microbiota changes with age, but it is not clear to what degree these changes are
due to physiologic changes, age-associated inflammation or immunosenescence, diet …

Throughout history, oral administration has been regarded as the most convenient mode of
drug delivery, as it requires minimal expertise and invasiveness. Although oral delivery …

Rationale: The elderly experience profound systemic responses after stroke, which
contribute to higher mortality and more severe long-term disability. Recent studies have …

Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance
and possibly to the longevity of the longest-lived rodent—the naked mole-rat,. To study …

Advancing age is accompanied by changes in the gut microbiota characterised by a loss of
beneficial commensal microbes that is driven by intrinsic and extrinsic factors such as diet …

The immune systems of post-pubescent males and females differ significantly with profound
consequences to health and disease. In many cases, sex-specific differences in the immune …

Increased inflammation associated with leaky gut is a major risk factor for morbidity and
mortality in older adults; however, successful preventive and therapeutic strategies against …

ABSTRACT A close symbiotic relationship exists between the intestinal microbiota and its
host. A critical component of gut homeostasis is the presence of a mucus layer covering the …

Commensal microbes and their multicellular eukaryotic hosts constitute a highly integrated
system—termed the holobiont [1]—which undergoes dynamic changes through time as it …

Gut microbiota is a potent biological modulator of many physiological and pathological
states. The renin-angiotensin system (RAS), including the local gastrointestinal RAS (GI …