[HTML][HTML] Specificity of oligonucleotide gene therapy (OGT) agents

DD Nedorezova, MV Dubovichenko, EP Belyaeva… - Theranostics, 2022 - ncbi.nlm.nih.gov
Oligonucleotide gene therapy (OGT) agents (eg antisense, deoxyribozymes, siRNA and
CRISPR/Cas) are promising therapeutic tools. Despite extensive efforts, only few OGT drugs …

Exosomal miRNAs as next-generation therapy vehicles in breast cancer

P Thakur, H Dahiya, A Kaushal, VK Gupta… - Current Gene …, 2023 - ingentaconnect.com
The second most pervasive cancer affecting the survival of women across the world is breast
cancer. One of the biggest challenges in breast cancer treatment is the chemoresistance of …

Mapping the function of MicroRNAs as a critical regulator of tumor-immune cell communication in breast cancer and potential treatment strategies

AS Abdul Manap, AA Wisham, FW Wong… - Frontiers in Cell and …, 2024 - frontiersin.org
Among women, breast cancer ranks as the most prevalent form of cancer, and the presence
of metastases significantly reduces prognosis and diminishes overall survival rates. Gaining …

The interaction between non-coding RNAs and SGLT2: A review

J Jarosz-Popek, C Eyileten, GM Gager, A Nowak… - International Journal of …, 2024 - Elsevier
Abstract Sodium-glucose cotransporter 2 (SGLT2, SLC5A2) is a promising target for a new
class of drug primarily established as kidney-targeting as well as emerging class of glucose …

Porcine reproductive and respiratory syndrome virus infection induces microRNA novel-216 production to facilitate viral-replication by targeting MAVS 3´ UTR

X Luo, S Xie, X Xu, Y Zhang, Y Huang, D Tan… - Veterinary …, 2024 - Elsevier
Porcine reproductive and respiratory syndrome virus (PRRSV) has caused significant
economic losses in the swine industry. In this study, the high-throughput sequencing …

MIR99AHG: a novel lncRNA host gene with diverse regulatory roles in cancer

J Si, X Su, H Xu, J Gu, Y Feng, Z Wang, Y Xiao… - Clinical Cancer …, 2024 - Springer
MIR99AHG, a recently discovered long non-coding RNA (lncRNA), serves as the host gene
for the miR-99a/let-7c/miR-125b-2 miRNA cluster. The intricate processing of its three …

miR-125b-5p 调控HK2 抑制胆囊癌细胞增殖和糖酵解.

张玮, 王保全, 雷喜锋, 王旭… - Journal of Kunming …, 2022 - search.ebscohost.com
目的研究miR-125b-5p 通过HK2 调控人胆囊癌细胞增殖和糖酵解的作用机制.
方法分别在人胆囊癌细胞GBC-SD 中转染NC mimic, miR-125b-5p mimic, miR-125b-5p …

miR-125b-5p Regulates HK2 to Inhibit Proliferation and Glycolysis of Gallbladder Cancer Cells

W ZHANG, W Baoquan, LEI Xifeng, W Xu… - 昆明医科大学 …, 2022 - kyxuebao.kmmu.edu.cn
Objective To investigate the mechanism of miR-125b-5p regulating the proliferation and
glycolysis of gallbladder cancer cells by HK2. Methods NC mimic, miR-125b-5p mimic, miR …