Biomineralization of skeletal components (eg, bone and teeth) is generally accepted to
occur under strict cellular regulation, leading to mineral–organic composites with …

In patients with breast cancer, lower bone mineral density increases the risk of bone
metastasis. Although the relationship between bone-matrix mineralization and tumour-cell …

In this review we highlighted the newest aspects concerning the physiopathology of breast
cancer metastatization into the bone including: a) in situ biomarkers of breast cancer …

Microcalcifications, primarily biogenic apatite, occur in cancerous and benign breast
pathologies and are key mammographic indicators. Outside the clinic, numerous …

Breast cancer frequently metastasizes to bone, causing osteolytic lesions. However, how
factors secreted by primary tumors affect the bone microenvironment before the osteolytic …

Osteosarcoma (OS) is the most common primary malignant bone cancer in children and
adolescents. While numerous other cancers now have promising therapeutic advances …

Mineral particles that form in soft tissues in association with disease conditions are
heterogeneous in their composition and physiochemical properties. Hence, it is challenging …

Nanohydroxyapatite (nHAP) has broad applications because of its nanoscopical dimension,
large specific surface area, biocompatibility, and low cytotoxicity. Researchers recently …

Microcalcification (MC) is a valuable diagnostic indicator of breast cancer, and it is reported
to be associated with increased tumor aggressiveness and poor prognosis. Nevertheless …

Reproducing in vitro a model of the bone microenvironment is a current need. Preclinical in
vitro screening, drug discovery, as well as pathophysiology studies may benefit from in vitro …