The 5′-nucleotidases are a family of enzymes that catalyze the dephosphorylation of
nucleoside monophosphates and regulate cellular nucleotide and nucleoside levels. While …

Mutations in the cytosolic 5′ nucleotidase II (NT5C2) gene drive resistance to thiopurine
chemotherapy in relapsed acute lymphoblastic leukemia (ALL). Mechanistically, NT5C2 …

Activating mutations in the cytosolic 5′-nucleotidase II gene NT5C2 drive resistance to 6-
mercaptopurine in acute lymphoblastic leukemia. Here we demonstrate that constitutively …

The 5′-nucleotidase (NT5) family of enzyme dephosphorylates non-cyclic nucleoside
monophosphates to produce nucleosides and inorganic phosphates. We hypothesized that …

Cytarabine (ara-C) requires activation into its triphosphorylated form, ara-CTP, to exert
cytotoxic activity. Cytoplasmic 5′-nucleotidase (5NT) dephosphorylates ara-CMP, a key …

Adenosine increases blood flow and decreases excitatory nerve firing. In the heart, it
reduces rate and force of contraction and preconditions the heart against injury by …

Cytosolic 5′-nucleotidase II catalyzes the dephosphorylation of 6-hydroxypurine
nucleoside 5′-monophosphates and regulates the IMP and GMP pools within the cell. It …

5′-Nucleotidase (EC 3.1. 3.5) designates a set of enzymes, which catalyze the hydrolysis of
ribonucleoside and deoxyribonucleoside monophosphates into the corresponding …

Cytosolic 5′-nucleotidase II (cN-II) catalyzes the dephosphorylation of 6-hydroxypurine
nucleoside 5′-monophosphates and participates in the regulation of purine nucleotide …

Elements of the nucleoside system (nucleoside levels, 5'-nucleotidases (5'NTs) and other
nucleoside metabolic enzymes, nucleoside transporters and nucleoside receptors) are …