Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

Background & Aims Hepatic stellate cells (HSCs) are vital to hepatocellular function and the
liver response to injury. They share a phenotypic homology with astrocytes that are central in …

Introduction: Chronic liver injury to hepatocytes or cholangiocytes, when left unmanaged,
leads to the development of liver fibrosis, a condition characterized by the excessive …

Pulmonary endothelial barrier dysfunction is a hallmark of clinical pulmonary edema and
contributes to the development of acute lung injury (ALI). Here we reported that ruscogenin …

Background and Purpose Portal hypertension is a lethal complication of cirrhosis. Its
mechanism and therapeutic targets remain largely unknown. Hepatic stellate cell (HSC) …

Background Scarring of the liver is the result of prolonged exposure to exogenous or
endogenous stimuli. At the onset of fibrosis, quiescent hepatic stellate cells (HSCs) activate …

Cancer metastasis plays a major role in tumor deterioration. Metastatic processes are known
to be regulated by hypoxic microenvironment and non-muscle myosin IIA (NMIIA). DT-13, a …

Type I collagen is extracellular matrix protein composed of two α1 (I) and one α2 (I)
polypeptides that fold into triple helix. Collagen polypeptides are translated in coordination …

P311 was first identified by the group of in the developing brain. In healthy, but mainly in
pathological tissues, P311 is implicated in cell migration and proliferation. Furthermore …

Three paralogues of nonmuscle myosin 2 (NM 2A, 2B, and 2C) are expressed in mammals,
and the heavy chains are the products of three different genes (Myh9, Myh10, and Myh14 …