Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer
T Boutros, E Chevet, P Metrakos - Pharmacological reviews, 2008 - ASPET
Mitogen-activated protein kinase dual-specificity phosphatase-1 (also called MKP-1,
DUSP1, ERP, CL100, HVH1, PTPN10, and 3CH134) is a member of the threonine-tyrosine …
DUSP1, ERP, CL100, HVH1, PTPN10, and 3CH134) is a member of the threonine-tyrosine …
Mapk signalling: Erk5 versus erk1/2
S Nishimoto, E Nishida - EMBO reports, 2006 - embopress.org
Extracellular‐signal‐regulated kinase 5 (ERK5) is a member of the mitogen‐activated
protein kinase (MAPK) family and, similar to ERK1/2, has the Thr–Glu–Tyr (TEY) activation …
protein kinase (MAPK) family and, similar to ERK1/2, has the Thr–Glu–Tyr (TEY) activation …
ERK5: structure, regulation and function
GN Nithianandarajah-Jones, B Wilm, CEP Goldring… - Cellular signalling, 2012 - Elsevier
Extracellular signal-regulated kinase 5 (ERK5), also termed big mitogen-activated protein
kinase-1 (BMK1), is the most recently identified member of the mitogen-activated protein …
kinase-1 (BMK1), is the most recently identified member of the mitogen-activated protein …
KLF 4 is a key determinant in the development and progression of cerebral cavernous malformations
R Cuttano, N Rudini, L Bravi, M Corada… - EMBO molecular …, 2016 - embopress.org
Cerebral cavernous malformations (CCM s) are vascular malformations located within the
central nervous system often resulting in cerebral hemorrhage. Pharmacological treatment is …
central nervous system often resulting in cerebral hemorrhage. Pharmacological treatment is …
Regulation of cellular functions by the ERK5 signalling pathway
X Wang, C Tournier - Cellular signalling, 2006 - Elsevier
Extracellular-regulated protein kinase 5 (ERK5) is a mitogen-activated protein kinase
(MAPK) regulated by a wide range of mitogens and cellular stresses. Since its cloning in …
(MAPK) regulated by a wide range of mitogens and cellular stresses. Since its cloning in …
[HTML][HTML] Dual-specificity phosphatase 6 (DUSP6): a review of its molecular characteristics and clinical relevance in cancer
Mitogen-activated protein kinases (MAPKs) are the main regulators of cellular proliferation,
growth, and survival in physiological or pathological conditions. Aberrant MAPK signaling …
growth, and survival in physiological or pathological conditions. Aberrant MAPK signaling …
Impact of ERK5 on the Hallmarks of Cancer
Extracellular signal-regulated kinase 5 (ERK5) belongs to the mitogen-activated protein
kinase (MAPK) family that consists of highly conserved enzymes expressed in all eukaryotic …
kinase (MAPK) family that consists of highly conserved enzymes expressed in all eukaryotic …
Identification of pharmacological inhibitors of the MEK5/ERK5 pathway
RJ Tatake, MM O'Neill, CA Kennedy, AL Wayne… - Biochemical and …, 2008 - Elsevier
We have identified two novel MEK5 inhibitors, BIX02188 and BIX02189, which inhibited
catalytic function of purified, MEK5 enzyme. The MEK5 inhibitors blocked phosphorylation of …
catalytic function of purified, MEK5 enzyme. The MEK5 inhibitors blocked phosphorylation of …
ERK5 kinase activity is dispensable for cellular immune response and proliferation
ECK Lin, CM Amantea… - Proceedings of the …, 2016 - National Acad Sciences
Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with
transcriptional activation capability in addition to an N-terminal canonical kinase domain …
transcriptional activation capability in addition to an N-terminal canonical kinase domain …
Oncogenic signaling of MEK5-ERK5
VT Hoang, TJ Yan, JE Cavanaugh, PT Flaherty… - Cancer letters, 2017 - Elsevier
Mitogen-activated protein kinases (MAPKs) regulate diverse cellular processes including
proliferation, cell survival, differentiation, and apoptosis. While conventional MAPK …
proliferation, cell survival, differentiation, and apoptosis. While conventional MAPK …