Most chronic inflammatory illnesses include fibrosis as a pathogenic characteristic.
Extracellular matrix (ECM) components build up in excess to cause fibrosis or scarring. The …

Dietary habits in the western world lead to increasing phosphate intake. Under physiological
conditions, extraosseous precipitation of phosphate with calcium is prevented by a mineral …

Background: Heart failure (HF) is a highly prevalent disorder for which disease mechanisms
are incompletely understood. The discovery of disease-associated proteins with causal …

Adipocyte differentiation of bone marrow mesenchymal stem/stromal cells (BMSCs) instead
of osteoblast formation contributes to age-and menopause-related marrow adiposity and …

Elevated levels of fibroblast growth factor 23 (FGF23) and phosphate are highly associated
with increased cardiovascular disease and mortality in patients suffering from chronic kidney …

In patients with chronic kidney disease (CKD), adverse outcomes such as systemic
inflammation and anemia are contributing pathologies which increase the risks for …

Vascular calcification (VC) predicts cardiovascular morbidity and mortality in chronic kidney
disease (CKD). To date, the underlying mechanisms remain unclear. We detected leukocyte …

Osteocytes, which represent up to 95% of adult skeletal cells, are deeply embedded in bone.
These cells exhibit important interactive abilities with other bone cells such as osteoblasts …

Fibroblast growth factor (FGF) 23 is a phosphate-regulating hormone that is elevated in
patients with chronic kidney disease and associated with cardiovascular mortality …

The phosphaturic hormone fibroblast growth factor 23 (FGF23) is a risk marker of
cardiovascular and all-cause mortality. We therefore aimed to synthesize the evidence for …