The epithelial to mesenchymal transition (EMT) in endometrial epithelial and trophectoderm
cells is essential for the progression of embryo implantation and its impairment could cause …

Tissue acidosis plays a pivotal role in tumor progression: in particular, interstitial acidosis
promotes tumor cell invasion, and is a major contributor to the dysregulation of tumor …

Cancer cells feature a resting membrane potential (V m) that is depolarized compared to
normal cells, and express active ionic conductances, which factor directly in their …

Background There is a critical need to better understand the mechanisms that drive local cell
invasion and metastasis to develop new therapeutics targeting metastatic disease …

Cancers of epithelial origin such as breast, prostate, cervical, gastric, colon and lung cancer
account for a large proportion of deaths worldwide. Better treatment of metastasis, the main …

Simple Summary Cancer, which is a major health problem, is a complex disease. Currently,
the main treatment methods are surgery, chemotherapy, radiotherapy and biological …

Simple Summary Colorectal cancer is a major cause of morbidity and mortality that affects
men and women equally. Here, we present the role of voltage-gated sodium channels (NaV) …

Over 90% of deaths in cancer patients are attributed to tumor drug resistance. Resistance to
therapeutic agents can be due to an innate property of cancer cells or can be acquired …

Voltage-gated sodium (Na V) channels, initially characterized in excitable cells, have been
shown to be aberrantly expressed in non-excitable cancer tissues and cells from epithelial …

Voltage-gated sodium channels (VGSCs), which are abnormally expressed in various types
of cancers such as breast cancer, prostate cancer, lung cancer, and cervical cancer, are …