The emerging mechanisms of Wnt secretion and signaling in development

S Mehta, S Hingole, V Chaudhary - Frontiers in Cell and …, 2021 - frontiersin.org
Wnts are highly-conserved lipid-modified secreted proteins that activate multiple signaling
pathways. These pathways regulate crucial processes during various stages of development …

Regulation of Wnt signaling pathways at the plasma membrane and their misregulation in cancer

Y Azbazdar, M Karabicici, E Erdal… - Frontiers in cell and …, 2021 - frontiersin.org
Wnt signaling is one of the key signaling pathways that govern numerous physiological
activities such as growth, differentiation and migration during development and …

Wnt/β‐catenin signaling: Structure, assembly and endocytosis of the signalosome

G Colozza, BK Koo - Development, growth & differentiation, 2021 - Wiley Online Library
Wnt/β‐catenin signaling is an ancient pathway that regulates key aspects of embryonic
development, cell differentiation, proliferation, and adult stem cell homeostasis. Work from …

The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells

A Takahashi-Kanemitsu, M Lu, CT Knight… - Science …, 2023 - science.org
Helicobacter pylori strains that deliver the oncoprotein CagA into gastric epithelial cells are
the major etiologic agents of upper gastric diseases including gastric cancer. CagA …

Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal

AM Pani, B Goldstein - Elife, 2018 - elifesciences.org
Wnts are evolutionarily conserved signaling proteins with essential roles in development
and disease that have often been thought to spread between cells and signal at a distance …

Engineered sulfated polysaccharides for biomedical applications

Ø Arlov, D Rütsche, M Asadi Korayem… - Advanced Functional …, 2021 - Wiley Online Library
Sulfated polysaccharides are ubiquitous in living systems and have central roles in
biological functions such as organism development, cell proliferation and differentiation …

Heparan sulfate proteoglycan clustering in Wnt signaling and dispersal

Y Mii, S Takada - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Wnt, a family of secreted signal proteins, serves diverse functions in animal development,
stem cell systems, and carcinogenesis. Although Wnt is generally considered a morphogen …

Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula

EJ Cooper, S Scholpp - Current Topics in Developmental Biology, 2024 - Elsevier
Within embryonic development, the occurrence of gastrulation is critical in the formation of
multiple germ layers with many differentiative abilities. These cells are instructed through …

Dysregulation of cellular membrane homeostasis as a crucial modulator of cancer risk

A Erazo‐Oliveras, M Muñoz‐Vega… - The FEBS …, 2024 - Wiley Online Library
Cellular membranes serve as an epicentre combining extracellular and cytosolic
components with membranous effectors, which together support numerous fundamental …

Genome-wide identification of potential odontogenic genes involved in the dental epithelium-mesenchymal interaction during early odontogenesis

J Chen, T Sun, Y You, B Lin, B Wu, J Wu - BMC genomics, 2023 - Springer
Background Epithelium-mesenchymal interactions are involved in odontogenic processes.
Previous studies have focused on the intracellular signalling regulatory network in tooth …