The emerging mechanisms of Wnt secretion and signaling in development
Wnts are highly-conserved lipid-modified secreted proteins that activate multiple signaling
pathways. These pathways regulate crucial processes during various stages of development …
pathways. These pathways regulate crucial processes during various stages of development …
Regulation of Wnt signaling pathways at the plasma membrane and their misregulation in cancer
Wnt signaling is one of the key signaling pathways that govern numerous physiological
activities such as growth, differentiation and migration during development and …
activities such as growth, differentiation and migration during development and …
Wnt/β‐catenin signaling: Structure, assembly and endocytosis of the signalosome
Wnt/β‐catenin signaling is an ancient pathway that regulates key aspects of embryonic
development, cell differentiation, proliferation, and adult stem cell homeostasis. Work from …
development, cell differentiation, proliferation, and adult stem cell homeostasis. Work from …
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells
A Takahashi-Kanemitsu, M Lu, CT Knight… - Science …, 2023 - science.org
Helicobacter pylori strains that deliver the oncoprotein CagA into gastric epithelial cells are
the major etiologic agents of upper gastric diseases including gastric cancer. CagA …
the major etiologic agents of upper gastric diseases including gastric cancer. CagA …
Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal
AM Pani, B Goldstein - Elife, 2018 - elifesciences.org
Wnts are evolutionarily conserved signaling proteins with essential roles in development
and disease that have often been thought to spread between cells and signal at a distance …
and disease that have often been thought to spread between cells and signal at a distance …
Engineered sulfated polysaccharides for biomedical applications
Sulfated polysaccharides are ubiquitous in living systems and have central roles in
biological functions such as organism development, cell proliferation and differentiation …
biological functions such as organism development, cell proliferation and differentiation …
Heparan sulfate proteoglycan clustering in Wnt signaling and dispersal
Wnt, a family of secreted signal proteins, serves diverse functions in animal development,
stem cell systems, and carcinogenesis. Although Wnt is generally considered a morphogen …
stem cell systems, and carcinogenesis. Although Wnt is generally considered a morphogen …
Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula
EJ Cooper, S Scholpp - Current Topics in Developmental Biology, 2024 - Elsevier
Within embryonic development, the occurrence of gastrulation is critical in the formation of
multiple germ layers with many differentiative abilities. These cells are instructed through …
multiple germ layers with many differentiative abilities. These cells are instructed through …
Dysregulation of cellular membrane homeostasis as a crucial modulator of cancer risk
A Erazo‐Oliveras, M Muñoz‐Vega… - The FEBS …, 2024 - Wiley Online Library
Cellular membranes serve as an epicentre combining extracellular and cytosolic
components with membranous effectors, which together support numerous fundamental …
components with membranous effectors, which together support numerous fundamental …
Genome-wide identification of potential odontogenic genes involved in the dental epithelium-mesenchymal interaction during early odontogenesis
J Chen, T Sun, Y You, B Lin, B Wu, J Wu - BMC genomics, 2023 - Springer
Background Epithelium-mesenchymal interactions are involved in odontogenic processes.
Previous studies have focused on the intracellular signalling regulatory network in tooth …
Previous studies have focused on the intracellular signalling regulatory network in tooth …