Prospective isolation of hematopoietic stem and progenitor cells has identified the lineal
relationships among all blood-cell types and has allowed their developmental mechanisms …

There is increasing evidence that the numerous mechanisms that regulate cell differentiation
during normal development are also involved in tumorigenesis. In breast cancer …

NFATc1 and NFATc2 are functionally redundant in the immune system, but it was suggested
that NFATc1 is required exclusively for differentiation of osteoclasts in the skeletal system …

Interplay among GATA transcription factors is an important determinant of cell fate during
hematopoiesis. Although GATA-2 regulates hematopoietic stem cell function, mechanisms …

The mechanism of lineage specification in multipotent stem cells has not been fully
understood. We recently isolated progenitors with the eosinophil, basophil, or mast cell …

Abstract Development of the lymphoid system is dependent on the Ets family transcription
factor PU. 1. We demonstrate that PU. 1−/− hematopoietic progenitors fail to express IL-7Rα …

In recent years, investigators have made great progress in delineating developmental
pathways of several lymphoid and myeloid lineages and in identifying transcription factors …

The differentiation of hematopoietic progenitors into erythroid or myeloid cell lineages is
thought to depend upon relative levels of the transcription factors gata1 and pu. 1. While loss …

GATA transcription factors are major regulators of hematopoietic and immune system.
Among GATA factors, GATA-1, GATA-2, and GATA-3 play crucial roles in the development of …

Hematopoiesis involves an elaborate regulatory network of transcription factors that
coordinates the expression of multiple downstream genes, and maintains homeostasis …