Ovarian cancer is the seventh most common gynaecologic malignancy seen in women.
Majority of the patients with ovarian cancer are diagnosed at the advanced stage making …

Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous
free radical whose predominant functions is that of a messenger through cGMP. In …

Gamma-glutamyltransferase (GGT) is a key enzyme involved in glutathione metabolism and
whose expression is often significantly increased in human malignancies. In the past years …

Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are three
endogenously produced gases with important functions in the vasculature, immune defense …

Tumor microenvironment is fundamental for cancer progression and chemoresistance.
Among stromal cells tumor-associated macrophages (TAMs) represent the largest …

In the last decade, immune therapies against human cancers have emerged as a very
effective therapeutic strategy in the treatment of various cancers, some of which are resistant …

Viruses have long been considered to be the most promising tools for human gene therapy.
However, the initial enthusiasm for the use of viruses has been tarnished in the light of …

Nitric oxide (NO) and its pro and anti-tumor activities are dual roles that continue to be
debated in cancer biology. The cell situations in the tumor and within the tumor …

Cancer is not a single disease but it constitutes a large variety of different types that are also
different from each other phenotypically and molecularly. Although the standard treatments …

Nitric oxide is a key second messenger in most tissues, where it is generated at low
concentrations, predominantly by the catalytic action of two constitutively expressed isoforms …