Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction

JG Paithankar, S Saini, S Dwivedi, A Sharma… - Chemosphere, 2021 - Elsevier
Heavy metal-induced cellular and organismal toxicity have become a major health concern
in biomedical science. Indiscriminate use of heavy metals in different sectors, such as …

Sources and toxicity of hexavalent chromium

R Saha, R Nandi, B Saha - Journal of Coordination Chemistry, 2011 - Taylor & Francis
Chromium exists in oxidation states ranging from− IV to+ VI, inclusively. The compounds
exhibit a wide range of geometries including square planar, tetrahedral, octahedral, and …

[HTML][HTML] The antagonistic effect of selenium on lead-induced apoptosis and necroptosis via P38/JNK/ERK pathway in chicken kidney

Z Miao, Z Miao, X Shi, H Wu, Y Yao, S Xu - … and environmental safety, 2022 - Elsevier
Lead (Pb), as a toxic heavy metal pollutant, has been paid much attention. Pb is often
discharged into the environment through the soot, wastewater and waste residue in …

Chromium genotoxicity: A double-edged sword

KP Nickens, SR Patierno, S Ceryak - Chemico-biological interactions, 2010 - Elsevier
Certain forms of hexavalent chromium [Cr (VI)] are known respiratory carcinogens that
induce a broad spectrum of DNA damage. Cr (VI)-carcinogenesis may be initiated or …

A review of chromium (Cr) epigenetic toxicity and health hazards

M Iyer, U Anand, S Thiruvenkataswamy… - Science of the Total …, 2023 - Elsevier
Carcinogenic metals affect a variety of cellular processes, causing oxidative stress and
cancer. The widespread distribution of these metals caused by industrial, residential …

JNK-induced apoptosis, compensatory growth, and cancer stem cells

F Chen - Cancer research, 2012 - AACR
Overwhelming) are a set of key stress-responsive kinases that mediate cell apoptosis, which
is an important process for tumor suppression. However, JNKs have also been implicated in …

Heavy metal pollution and its relation to the malformation of green mussels cultured in Muara Kamal waters, Jakarta Bay, Indonesia

E Riani, MR Cordova, Z Arifin - Marine pollution bulletin, 2018 - Elsevier
Jakarta Bay has become contaminated by both organic and inorganic pollutants, including
heavy metals. This study aimed to examine the effect of heavy metal pollution on green …

Luteolin inhibits Cr (VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways

P Pratheeshkumar, YO Son, SP Divya, RV Roy… - Toxicology and applied …, 2014 - Elsevier
Abstract Hexavalent chromium [Cr (VI)] is a well-known human carcinogen associated with
the incidence of lung cancer. Inhibition of metal induced carcinogenesis by a dietary …

Early‐Responsive Immunoregulation Therapy Improved Microenvironment for Bone Regeneration Via Engineered Extracellular Vesicles

T Lu, Y Liu, X Huang, S Sun, H Xu, A Jin… - Advanced …, 2024 - Wiley Online Library
Overactivated inflammatory reactions hinder the bone regeneration process. Timely
transformation of microenvironment from pro‐inflammatory to anti‐inflammatory after acute …

Heavy metals, oxidative stress, and the role of AhR signaling

Z Kou, F Tran, W Dai - Toxicology and Applied Pharmacology, 2024 - Elsevier
Abstract The Aryl Hydrocarbon Receptor (AhR) is a ligand-activated transcriptional factor
pivotal in responding to environmental stress and maintaining cellular homeostasis …