Tissues are dynamically shaped by bidirectional communication between resident cells and
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …

Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …

Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is
accomplished primarily through the integrin family of cell-surface receptors. Integrins are …

Integrin receptors are the main molecular link between cells and the extracellular matrix
(ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the …

The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM)
macromolecules filled with a collection of cells including cancer-associated fibroblasts …

Background Extracellular matrix (ECM) is a dynamic and complex environment
characterized by biophysical, mechanical and biochemical properties specific for each …

Interlocking gene mutations, epigenetic alterations and microenvironmental features
perpetuate tumor development, growth, infiltration and spread. Consequently, intrinsic and …

It is widely acknowledged that integrins, the major receptors for the extracellular matrix
(ECM) proteins, exert an extensive crosstalk with many growth factor and cytokine receptors …

Integrins are cell adhesion receptors, which are typically transmembrane glycoproteins that
connect to the extracellular matrix (ECM). The function of integrins regulated by biochemical …

Integrins mediate adhesive interactions between cells and their environment, including
neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane …