[HTML][HTML] Cerebellar pathology in motor neuron disease: neuroplasticity and neurodegeneration

RH Chipika, G Mulkerrin, PF Pradat… - Neural regeneration …, 2022 - journals.lww.com
Amyotrophic lateral sclerosis is a relentlessly progressive multi-system condition. The
clinical picture is dominated by upper and lower motor neuron degeneration, but extra-motor …

[HTML][HTML] Neurometabolic alterations in motor neuron disease: insights from magnetic resonance spectroscopy

F Christidi, E Karavasilis, GD Argyropoulos… - Journal of integrative …, 2022 - imrpress.com
Magnetic resonance spectroscopy (MRS) has contributed important academic insights in
motor neuron diseases (MNDs), particularly in amyotrophic lateral sclerosis (ALS). Over the …

[HTML][HTML] Pathological neural networks and artificial neural networks in ALS: diagnostic classification based on pathognomonic neuroimaging features

P Bede, A Murad, O Hardiman - Journal of neurology, 2021 - Springer
The description of group-level, genotype-and phenotype-associated imaging traits is
academically important, but the practical demands of clinical neurology centre on the …

Diffusion tensor imaging-based multi-fiber tracking reconstructions can regionally differentiate phonetic versus prosodic subtypes of progressive apraxia of speech

RG Gatto, PR Martin, RL Utianski, JR Duffy, HM Clark… - Cortex, 2024 - Elsevier
Two subtypes of progressive apraxia of speech (PAOS) have been recognized: phonetic
PAOS (PAOS_ph) where speech output is dominated by distorted sound substitutions and …

The changing landscape of neuroimaging in frontotemporal lobar degeneration: From group-level observations to single-subject data interpretation

MC McKenna, A Murad, W Huynh, J Lope… - Expert review of …, 2022 - Taylor & Francis
Introduction While the imaging signatures of frontotemporal lobar degeneration (FTLD)
phenotypes and genotypes are well-characterized based on group-level descriptive …

Cerebellar degeneration in primary lateral sclerosis: an under-recognized facet of PLS

E Finegan, WF Siah, S Li Hi Shing… - … Lateral Sclerosis and …, 2022 - Taylor & Francis
While primary lateral sclerosis (PLS) has traditionally been regarded as a pure upper motor
neuron disorder, recent clinical, neuroimaging and postmortem studies have confirmed …

[HTML][HTML] Hemispheric cortical, cerebellar and caudate atrophy associated to cognitive impairment in Metropolitan Mexico City young adults exposed to fine particulate …

L Calderón-Garcidueñas, J Hernández-Luna… - Toxics, 2022 - mdpi.com
Exposures to fine particulate matter PM2. 5 are associated with Alzheimer's, Parkinson's
(AD, PD) and TDP-43 pathology in young Metropolitan Mexico City (MMC) residents. High …

[HTML][HTML] Supra-and infra-tentorial degeneration patterns in primary lateral sclerosis: a multimodal longitudinal neuroradiology study

J Kleinerova, M Tahedl, EL Tan, S Delaney… - Journal of …, 2024 - Springer
Background Primary lateral sclerosis (PLS) is traditionally solely associated with progressive
upper motor neuron dysfunction manifesting in limb spasticity, gait impairment, bulbar …

[HTML][HTML] Evaluation and categorisation of individual patients based on white matter profiles: Single-patient diffusion data interpretation in neurodegeneration

M Tahedl, A Murad, J Lope, O Hardiman… - Journal of the neurological …, 2021 - Elsevier
The majority of radiology studies in neurodegenerative conditions infer group-level imaging
traits from group comparisons. While this strategy is helpful to define phenotype-specific …

[HTML][HTML] Pre-symptomatic radiological changes in frontotemporal dementia: propagation characteristics, predictive value and implications for clinical trials

MC McKenna, J Lope, EL Tan, P Bede - Brain imaging and behavior, 2022 - Springer
Computational imaging and quantitative biomarkers offer invaluable insights in the pre-
symptomatic phase of neurodegenerative conditions several years before clinical …