Emerging therapeutic opportunities for integrin inhibitors
Integrins are cell adhesion and signalling proteins crucial to a wide range of biological
functions. Effective marketed treatments have successfully targeted integrins αIIbβ3 …
functions. Effective marketed treatments have successfully targeted integrins αIIbβ3 …
Integrins as biomechanical sensors of the microenvironment
Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …
[HTML][HTML] Integrin signaling in cancer: mechanotransduction, stemness, epithelial plasticity, and therapeutic resistance
J Cooper, FG Giancotti - Cancer cell, 2019 - cell.com
Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell
interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor …
interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor …
Targeting the tumour vasculature: from vessel destruction to promotion
S Guelfi, K Hodivala-Dilke, G Bergers - Nature Reviews Cancer, 2024 - nature.com
As angiogenesis was recognized as a core hallmark of cancer growth and survival, several
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …
Cell adhesion by integrins
M Bachmann, S Kukkurainen… - Physiological …, 2019 - journals.physiology.org
Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …
between cells and the extracellular matrix. In addition to the anchorage of cells to the …
Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy?
RR Ramjiawan, AW Griffioen, DG Duda - Angiogenesis, 2017 - Springer
Angiogenesis is defined as the formation of new blood vessels from preexisting vessels and
has been characterized as an essential process for tumor cell proliferation and viability. This …
has been characterized as an essential process for tumor cell proliferation and viability. This …
Single-breath-hold photoacoustic computed tomography of the breast
We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT)
system to reveal detailed angiographic structures in human breasts. SBH-PACT features a …
system to reveal detailed angiographic structures in human breasts. SBH-PACT features a …
RGD-binding integrins revisited: how recently discovered functions and novel synthetic ligands (re-) shape an ever-evolving field
Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …
investigated as therapeutic targets over the last decades, motivated by their multiple …
Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study …
Background Cilengitide is a selective αvβ3 and αvβ5 integrin inhibitor. Data from phase 2
trials suggest that it has antitumour activity as a single agent in recurrent glioblastoma and in …
trials suggest that it has antitumour activity as a single agent in recurrent glioblastoma and in …
Exploring the role of RGD-recognizing integrins in cancer
M Nieberler, U Reuning, F Reichart, J Notni, HJ Wester… - Cancers, 2017 - mdpi.com
Integrins are key regulators of communication between cells and with their
microenvironment. Eight members of the integrin superfamily recognize the tripeptide motif …
microenvironment. Eight members of the integrin superfamily recognize the tripeptide motif …