The environmental and metabolic pressures in the tumor microenvironment (TME) play a
key role in molding tumor development by impacting the stromal and immune cell fractions …

The management of patients with glioma usually requires multimodality treatment including
surgery, radiotherapy, and systemic therapy. Accurate neuroimaging plays a central role for …

Hypoxia at the solid tumor site is generally related to the unrestricted proliferation and
metabolism of cancerous cells, which can cause tumor metastasis and aggravate tumor …

Over the last few years, cancer immunotherapy experienced tremendous developments and
it is nowadays considered a promising strategy against many types of cancer. However, the …

Background Gliomas are complex tumors with several genetic aberrations and diverse
metabolic programs contributing to their aggressive phenotypes and poor prognoses. This …

Hypoxia is one of the prominent features of solid tumors. Hypoxia activated prodrugs
(HAPs), selectively killing hypoxic cells, possess the potential to transform hypoxia from a …

The hypoxic state in a solid tumor refers to the internal hypoxic environment that appears as
the tumor volume increases (the maximum radius exceeds 180-200 microns). This state can …

Malignant glioma represents a fatal disease with a poor prognosis and development of
resistance mechanisms against conventional therapeutic approaches. The distinct tumor …

Target population These recommendations apply to adults with a newly diagnosed lesion
with a suspected or histopathologically proven glioblastoma (GBM). Question What are the …

In this study, we describe a one-pot three-component synthesis of bioactive
tetrahydopyrimidinecarboxamide derivatives employing lanthanum triflate as a catalyst. Out …