Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …

Epistasis plays an important role in the genetic architecture of common human diseases and
can be viewed from two perspectives, biological and statistical, each derived from and …

Detecting, characterizing, and interpreting gene–gene interactions or epistasis in studies of
human disease susceptibility is both a mathematical and a computational challenge. To …

Epistatic interactions among multiple genetic variants in the human genome may be
important in determining individual susceptibility to common diseases. Although some …

Motivation: Widespread availability of low-cost, full genome sequencing will introduce new
challenges for bioinformatics. Results: This review outlines recent developments in …

Multifactor dimensionality reduction (MDR) was developed as a method for detecting
statistical patterns of epistasis. The overall goal of MDR is to change the representation …

Background The key roles of epistatic interactions between multiple genetic variants in the
pathogenesis of complex diseases notwithstanding, the detection of such interactions …

G protein-coupled receptors (GPCRs) are important regulators of various cellular functions
via activation of intracellular signaling events. Active GPCR signaling is shut down by GPCR …

Complex interactions among genes and environmental factors are known to play a role in
common human disease aetiology. There is a growing body of evidence to suggest that …

Understanding the relationship between DNA sequence variations and biologic traits is
expected to improve the diagnosis, prevention and treatment of common human diseases …