Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Ischaemic stroke
Stroke is the second highest cause of death globally and a leading cause of disability, with
an increasing incidence in developing countries. Ischaemic stroke caused by arterial …
an increasing incidence in developing countries. Ischaemic stroke caused by arterial …
Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination
M Zirngibl, P Assinck, A Sizov, AV Caprariello… - Molecular …, 2022 - Springer
Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …
to induce demyelination of specific brain structures and is widely used as model of multiple …
The role of NMDA receptors in Alzheimer's disease
J Liu, L Chang, Y Song, H Li, Y Wu - Frontiers in neuroscience, 2019 - frontiersin.org
In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …
[PDF][PDF] A brief history of long-term potentiation
RA Nicoll - neuron, 2017 - cell.com
Since the discovery of long-term potentiation (LTP) in 1973, thousands of papers have been
published on this intriguing phenomenon, which provides a compelling cellular model for …
published on this intriguing phenomenon, which provides a compelling cellular model for …
[HTML][HTML] Magnesium in man: implications for health and disease
JHF De Baaij, JGJ Hoenderop… - Physiological …, 2015 - journals.physiology.org
Abstract Magnesium (Mg 2+) is an essential ion to the human body, playing an instrumental
role in supporting and sustaining health and life. As the second most abundant intracellular …
role in supporting and sustaining health and life. As the second most abundant intracellular …
[HTML][HTML] Excitotoxicity: still hammering the ischemic brain in 2020
DW Choi - Frontiers in neuroscience, 2020 - frontiersin.org
Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic
brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate …
brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate …
[PDF][PDF] Structural and functional architecture of AMPA-type glutamate receptors and their auxiliary proteins
IH Greger, JF Watson, SG Cull-Candy - Neuron, 2017 - cell.com
AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
[PDF][PDF] AMPARs and synaptic plasticity: the last 25 years
RL Huganir, RA Nicoll - Neuron, 2013 - cell.com
The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas
of research in neuroscience. In the last 25 years we have come a long way in our …
of research in neuroscience. In the last 25 years we have come a long way in our …
[HTML][HTML] Imaging calcium in neurons
C Grienberger, A Konnerth - Neuron, 2012 - cell.com
Calcium ions generate versatile intracellular signals that control key functions in all types of
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …