The main interfaces controlling and attempting to homeostatically balance communications
between the host and the environment are the epithelial barriers of the skin, gastrointestinal …

The cell–cell connections in adherens junctions (AJs) are mediated by transmembrane
receptors, type I cadherins (referred to here as cadherins). These cadherin-based …

Background Although atopic dermatitis (AD) often presents in infancy and persists into
adulthood, comparative characterization of AD skin among different pediatric age groups is …

Biological barriers are essential physiological protective systems and obstacles to drug
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …

Tight junctions (TJ) play a central role in the homeostasis of epithelial and endothelial
tissues, by providing a semipermeable barrier to ions and solutes, by contributing to the …

The epithelial cell tight junction structure is the site of the transepithelial movement of solutes
and water between epithelial cells (paracellular permeability). Paracellular permeability can …

Claudin-2 is expressed in the tight junctions of leaky epithelia, where it forms cation-
selective and water permeable paracellular channels. Its abundance is under fine control by …

Endothelial cells line all blood vessels, where they coordinate blood vessel formation and
the blood-tissue barrier via regulation of cell-cell junctions. The nucleus also regulates …

The development of adhesive connections between cells was critical for the evolution of
multicellularity and for organizing cells into complex organs with discrete compartments …

Tight junctions (TJ) are cell–cell adhesive structures that define the permeability of barrier-
forming epithelia and endothelia. In contrast to this seemingly static function, TJs display a …