The hand endows us with unparalleled precision and versatility in our interactions with
objects, from mundane activities such as grasping to extraordinary ones such as virtuoso …

Stroke instigates a dynamic process of repair and remodelling of remaining neural circuits,
and this process is shaped by behavioural experiences. The onset of motor disability …

An account of the neurobiology of motor recovery in the arm and hand after stroke by two
experts in the field. Stroke is a leading cause of disability in adults and recovery is often …

Motor cortex (M1) has lateralized outputs, yet neurons can be active during movements of
either arm. What is the nature and role of activity across the two hemispheres? We recorded …

Prehension, the capacity to reach and grasp, is the key behavior that allows humans to
change their environment. It continues to serve as a remarkable experimental test case for …

Highlights•Convergence between axon regeneration ability and abnormal synaptic structure
and function.•Axon regeneration, neuronal circuit assembly and recovery of functions in the …

One of the primary ways we interact with the world is using our hands. In macaques, the
circuit spanning the anterior intraparietal area, the hand area of the ventral premotor cortex …

In primates, neural mechanisms for controlling skilled hand actions primarily rely on
sensorimotor transformations. These transformations are mediated by circuits linking specific …

Motor cortex (M1) lesions result in motor impairments, yet how M1 contributes to the control
of movement remains controversial. To investigate the role of M1 in sensory guided motor …

Background Evidence from animal studies suggests that greater reductions in poststroke
motor impairment can be attained with significantly higher doses and intensities of therapy …