Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

Fibrosis is a chronic and progressive disorder characterized by excessive deposition of
extracellular matrix, which leads to scarring and loss of function of the affected organ or …

Fibroblasts are rich in the surrounding microenvironment of hepatocellular carcinoma (HCC)
because most HCCs occur in fibrotic or cirrhotic livers. However, the role of cancer …

Liver disease remains a leading cause of mortality worldwide despite recent successes in
the field of viral hepatitis, because increases in alcohol consumption and obesity are fuelling …

Background & Aims The prevalence of non-alcoholic fatty liver disease (NAFLD) and its
severe form, non-alcoholic steatohepatitis (NASH), is increasing. Individuals with NASH …

Sonic hedgehog (Shh) signaling is an essential central nervous system (CNS) pathway
involved during embryonic development and later life stages. Further, it regulates cell …

Adult liver has enormous regenerative capacity; it can regenerate after losing two-thirds of its
mass while sustaining essential metabolic functions. How the liver balances dual demands …

Obesity and diabetes represent key healthcare challenges of our day, affecting upwards of
one billion people worldwide. These individuals are at higher risk for cancer, stroke …

Background & Aims Liver fibrosis is an increasing health concern worldwide and a major
risk factor for hepatocellular carcinoma (HCC). Although the involvement of Hedgehog …

Non-alcoholic fatty liver (NAFL) is a prevalent hepatic disorder of global significance that can
give rise to severe complications. This research endeavor delves into the potential of nano …