Inflammation is strictly associated with cancer and plays a key role in tumor development
and progression. Several epidemiological studies have demonstrated that inflammation can …

Abstract On March 16, 2023, the FDA approved dabrafenib in combination with trametinib
(Tafinlar, Mekinist; Novartis Pharmaceuticals Corporation) for the treatment of pediatric …

Arteriovenous malformation (AVM) is a fast-flow, congenital vascular anomaly that may arise
anywhere in the body. AVMs typically progress, causing destruction of surrounding tissue …

Although the biological basis of hepatocellular carcinoma (HCC) remains unclear, effective
treatments and improvement of the survival rate remain worthwhile research goals …

Leishmania spp. and Trypanosoma cruzi are the causative agents of leishmaniasis and
Chagas disease, respectively, two neglected tropical diseases that affect about 25 million …

Simple Summary The Ras-Raf-MEK-ERK signaling pathway is responsible for regulating
cell proliferation, differentiation, and survival. Overexpression and overactivation of …

The Nuclear factor erythroid2-related factor2 (Nrf2), a master regulator of redox
homoeostasis, is a key transcription factor regulating a wide array of genes for antioxidant …

PURPOSE The NCI-COG Pediatric MATCH trial assigns patients age 1-21 years with
relapsed or refractory solid tumors, lymphomas, and histiocytic disorders to phase II studies …

RAS pathway mutations have been linked to relapse and chemotherapy resistance in
pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However …

The receptor tyrosine kinase MERTK is aberrantly expressed in numerous human
malignancies, and is a novel target in cancer therapeutics. Physiologic roles of MERTK …