Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug
compounds that limits in vivo bioavailability owing to their low dissolution rate in the …

Identification of lead compounds with higher molecular weight and lower aqueous solubility
has become increasingly prevalent with the advent of high throughput screening. Poor …

There is an increased evidence for treating hypertension by a combination of two or more
drugs. Increasing the number of daily intake of tablets has been reported to negatively affect …

There is a great interest to develop co-amorphous drug delivery systems to enhance the
solubility of biopharmaceutics classification system (BCS) class II and IV drugs. However …

Engineered cocrystals offer an alternative solid drug form with tailored physicochemical
properties. Interestingly, although cocrystals provide many new possibilities, they also …

The alarming numbers of poorly soluble discovery compounds have centered the efforts
towards finding strategies to improve the solubility. One of the attractive approaches to …

Novel raft forming systems incorporating curcumin-Eudragit® EPO solid dispersions were
developed to prolong the gastric residence time and provide for a controlled release therapy …

The objective was to use caffeine and Soluplus® to improve the dissolution rate and to
maintain a concentration of BCS Class II rosuvastatin calcium that exceeds its solubility …

Recently developed high-throughput in vitro assays in combination with computational
models could provide alternatives to animal testing. The purpose of the present study was to …

In this study, we investigated the formation of a co-amorphous system of tranilast (TRL) and
diphenhydramine hydrochloride (DPH), which are drugs used for treating allergies and …