The multifaceted roles of copper in cancer: A trace metal element with dysregulated metabolism, but also a target or a bullet for therapy
Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …
can be detrimental for the cell that developed highly coordinated pathways to chelate and …
Cyclin-dependent kinases in breast cancer: expression pattern and therapeutic implications
Presently, breast cancer (BC) is one of the most common malignancies diagnosed and the
leading cause of tumor-related deaths among women worldwide. Cell cycle dysregulation is …
leading cause of tumor-related deaths among women worldwide. Cell cycle dysregulation is …
[HTML][HTML] Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer
B Győrffy - Computational and structural biotechnology journal, 2021 - Elsevier
Introduction Extensive research is directed to uncover new biomarkers capable to stratify
breast cancer patients into clinically relevant cohorts. However, the overall performance …
breast cancer patients into clinically relevant cohorts. However, the overall performance …
Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment
Y Zheng, Z Chen, Y Han, L Han, X Zou, B Zhou… - Nature …, 2020 - nature.com
Cancer immunotherapy has revolutionized cancer treatment, and it relies heavily on the
comprehensive understanding of the immune landscape of the tumor microenvironment …
comprehensive understanding of the immune landscape of the tumor microenvironment …
Metastasis and immune evasion from extracellular cGAMP hydrolysis
Cytosolic DNA is characteristic of chromosomally unstable metastatic cancer cells, resulting
in constitutive activation of the cGAS–STING innate immune pathway. How tumors co-opt …
in constitutive activation of the cGAS–STING innate immune pathway. How tumors co-opt …
Long noncoding RNA MALAT1 suppresses breast cancer metastasis
MALAT1 has previously been described as a metastasis-promoting long noncoding RNA
(lncRNA). We show here, however, that targeted inactivation of the Malat1 gene in a …
(lncRNA). We show here, however, that targeted inactivation of the Malat1 gene in a …
Chromosomal instability drives metastasis through a cytosolic DNA response
Chromosomal instability is a hallmark of cancer that results from ongoing errors in
chromosome segregation during mitosis. Although chromosomal instability is a major driver …
chromosome segregation during mitosis. Although chromosomal instability is a major driver …
Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors
Cell cycle dysregulation is a characteristic hallmark of malignancies, which results in
uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 …
uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 …
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression
Stromal stiffening accompanies malignancy, compromises treatment and promotes tumour
aggression. Clarifying the molecular nature and the factors that regulate stromal stiffening in …
aggression. Clarifying the molecular nature and the factors that regulate stromal stiffening in …
Proteomic analysis of archival breast cancer clinical specimens identifies biological subtypes with distinct survival outcomes
Despite advances in genomic classification of breast cancer, current clinical tests and
treatment decisions are commonly based on protein level information. Formalin-fixed …
treatment decisions are commonly based on protein level information. Formalin-fixed …