Insulin-like growth factors (IGFs) play important roles in mammalian growth, development,
aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and …

Insulin-like growth factor 2 (IGF2) is a 7.5 kDa mitogenic peptide hormone expressed by liver
and many other tissues. It is three times more abundant in serum than IGF1, but our …

Aim To review and discuss the available international literature regarding the indirect and
direct biochemical mechanisms that occur after exercise, which could positively, or …

Benign prostate hyperplasia (BPH), one of the most common diseases in older men,
adversely affects quality-of-life due to the presence of low urinary tract symptoms (LUTS) …

Metformin is widely prescribed for the treatment of type II diabetes. Recently, it has been
proposed that this compound or related biguanides may have antineoplastic activity …

Elucidating the determinants of aggressiveness in lethal prostate cancer may stimulate
therapeutic strategies that improve clinical outcomes. We used experimental models and …

Nutrition, physical activity, and lifestyle factors in prost... : Current Opinion in Urology Nutrition,
physical activity, and lifestyle factors in prostate cancer prevention : Current Opinion in Urology …

Androgen/androgen receptor (AR) signaling plays important roles in normal liver function
and in progression of liver diseases. In studies of noncancerous liver diseases, AR knockout …

Introduction Exercise is one of several factors known to lower the risk of developing cancer,
as well as improve outcomes in patients already diagnosed. People who exercise after …

Background Over the past two decades, parallel recognition has grown of the importance of
both sex steroids and immune activity in metabolic regulation. More recently, these discrete …