RGD-binding integrins revisited: how recently discovered functions and novel synthetic ligands (re-) shape an ever-evolving field

BS Ludwig, H Kessler, S Kossatz, U Reuning - Cancers, 2021 - mdpi.com
Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

Cell penetration: scope and limitations by the application of cell‐penetrating peptides

S Reissmann - Journal of Peptide Science, 2014 - Wiley Online Library
The penetration of polar or badly soluble compounds through a cell membrane into live cells
requires mechanical support or chemical helpers. Cell‐penetrating peptides (CPPs) are very …

[HTML][HTML] A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins

TG Kapp, F Rechenmacher, S Neubauer, OV Maltsev… - Scientific reports, 2017 - nature.com
Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell
structure and behaviour, affecting cell morphology, proliferation, survival and differentiation …

[HTML][HTML] Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery

J Schnittert, R Bansal, G Storm, J Prakash - Advanced drug delivery reviews, 2018 - Elsevier
Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well.
Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which …

Tumor targeting via integrin ligands

UK Marelli, F Rechenmacher, TRA Sobahi… - Frontiers in …, 2013 - frontiersin.org
Selective and targeted delivery of drugs to tumors is a major challenge for an effective
cancer therapy and also to overcome the side-effects associated with current treatments …

Advancement in integrin facilitated drug delivery

D Arosio, C Casagrande - Advanced Drug Delivery Reviews, 2016 - Elsevier
The research of integrin-targeted anticancer agents has recorded important advancements
in ingenious design of delivery systems, based either on the prodrug approach, or on …

Integrin clustering matters: a review of biomaterials functionalized with multivalent integrin‐binding ligands to improve cell adhesion, migration, differentiation …

F Karimi, AJ O'Connor, GG Qiao… - Advanced healthcare …, 2018 - Wiley Online Library
Material systems that exhibit tailored interactions with cells are a cornerstone of biomaterial
and tissue engineering technologies. One method of achieving these tailored interactions is …

Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting

J Liu, H Long, D Zeuschner, AFB Räder… - Nature …, 2021 - nature.com
A major deficit in tissue engineering strategies is the lack of materials that promote
angiogenesis, wherein endothelial cells from the host vasculature invade the implanted …

αvβ3‐or α5β1‐integrin‐selective peptidomimetics for surface coating

C Mas‐Moruno, R Fraioli… - Angewandte Chemie …, 2016 - Wiley Online Library
Engineering biomaterials with integrin‐binding activity is a very powerful approach to
promote cell adhesion, modulate cell behavior, and induce specific biological responses at …

Thermo-responsive hydrogel layers imprinted with RGDS peptide: a system for harvesting cell sheets.

G Pan, Q Guo, Y Ma, H Yang… - Angewandte Chemie …, 2013 - search.ebscohost.com
The article offers information on the introduction of the cell adhesive peptide Arg-Gly-Asp-
Ser (RGDS) onto a thermo-responsive cell culture substrate which was used as a novel …