Labeling of nucleic acids is required for many studies aiming to elucidate their functions and
dynamics in vitro and in cells. Out of the numerous labeling concepts that have been …

RNA is a unique bio-macromolecule that can both record genetic information and perform
biological functions in a variety of molecular processes, including transcription, splicing …

Cas12a, also known as Cpf1, is a type VA CRISPR-Cas RNA-guided endonuclease that is
used for genome editing based on its ability to generate specific dsDNA breaks. Here, we …

Overcoming limitations of previous fluorescent light-up RNA aptamers for super-resolution
imaging, we present RhoBAST, an aptamer that binds a fluorogenic rhodamine dye with fast …

Transcriptional riboswitches involve RNA aptamers that are typically found in the 5′
untranslated regions (UTRs) of bacterial mRNAs and form alternative secondary structures …

The mRNA modification N6‐methyladenosine (m6A) is associated with multiple roles in cell
function and disease. The methyltransferases METTL3‐METTL14 and METTL16 act as …

Conformational dynamics of biomolecules are of fundamental importance for their function.
Single-molecule studies of Förster Resonance Energy Transfer (smFRET) between a …

The introduction of chemical modifications into long RNA molecules at specific positions for
visualization, biophysical investigations, diagnostic and therapeutic applications still …

A major hallmark of Alzheimer's disease is the misfolding and aggregation of the amyloid-β
peptide (Aβ). While early research pointed towards large fibrillar-and plaque-like aggregates …

The functional diversity of RNAs is encoded in their innate conformational heterogeneity.
The combination of single-molecule spectroscopy and computational modeling offers new …