Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells

J Zhou, Y Nefedova, A Lei, D Gabrilovich - Seminars in immunology, 2018 - Elsevier
Neutrophils and polymorphonucler myeloid-derived suppressor cells (PMN-MDSC) share
origin and many morphological and phenotypic features. However, they have different …

Monocytic myeloid-derived suppressor cells in chronic infections

A Dorhoi, N Du Plessis - Frontiers in immunology, 2018 - frontiersin.org
Heterogeneous populations of myeloid regulatory cells (MRC), including monocytes,
macrophages, dendritic cells, and neutrophils, are found in cancer and infectious diseases …

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

LJ Pallett, US Gill, A Quaglia, LV Sinclair… - Nature medicine, 2015 - nature.com
Infection with hepatitis B virus (HBV) results in disparate degrees of tissue injury: the virus
can either replicate without pathological consequences or trigger immune-mediated …

Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer

JI Youn, V Kumar, M Collazo, Y Nefedova… - Nature …, 2013 - nature.com
Two major populations of myeloid-derived suppressor cells (MDSCs), monocytic MDSCs (M-
MDSCs) and polymorphonuclear MDSCs (PMN-MDSCs) regulate immune responses in …

Reciprocal relationship between myeloid-derived suppressor cells and T cells

S Nagaraj, JI Youn, DI Gabrilovich - The Journal of Immunology, 2013 - journals.aai.org
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells that
play a major role in the regulation of immune responses in many pathological conditions …

Innate immune sensing and response to influenza

B Pulendran, MS Maddur - Influenza Pathogenesis and Control-Volume II, 2015 - Springer
Influenza viruses pose a substantial threat to human and animal health worldwide. Recent
studies in mouse models have revealed an indispensable role for the innate immune system …

Escape from X chromosome inactivation and female bias of autoimmune diseases

MJ Mousavi, M Mahmoudi, S Ghotloo - Molecular Medicine, 2020 - Springer
Generally, autoimmune diseases are more prevalent in females than males. Various
predisposing factors, including female sex hormones, X chromosome genes, and the …

Respiratory viral infections and host responses; insights from genomics

NM Troy, A Bosco - Respiratory research, 2016 - Springer
Respiratory viral infections are a leading cause of disease and mortality. The severity of
these illnesses can vary markedly from mild or asymptomatic upper airway infections to …

STAT1-regulated lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumonia

SL Poe, M Arora, TB Oriss, M Yarlagadda, K Isse… - Mucosal …, 2013 - nature.com
Bacterial pneumonia remains a significant burden worldwide. Although an inflammatory
response in the lung is required to fight the causative agent, persistent tissue-resident …

Granulocytic myeloid-derived suppressor cells accumulate in human placenta and polarize toward a Th2 phenotype

N Köstlin, K Hofstädter, AL Ostermeir… - The Journal of …, 2016 - journals.aai.org
Tolerance induction toward the semiallogeneic fetus is crucial to enable a successful
pregnancy; its failure is associated with abortion or preterm delivery. Skewing T cell …