Corneal wound healing is a complex process involving cell death, migration, proliferation,
differentiation, and extracellular matrix remodeling. Many similarities are observed in the …

The ocular surface microbiota refers to the resident non-pathogenic microorganisms that
colonize conjunctiva and cornea. Several studies have shown that ocular surface epithelial …

Contact lenses represent a widely utilized form of vision correction with more than 140
million wearers worldwide. Although generally well-tolerated, contact lenses can cause …

The eye and the brain are immunologically privileged sites, a property previously attributed
to the lack of a lymphatic circulation. However, recent tracking studies confirm that these …

SUMMARY Human alphaherpesvirus 1 (HSV-1) is a highly successful neurotropic pathogen
that primarily infects the epithelial cells lining the orofacial mucosa. After primary lytic …

Bacterial infections of the cornea, or bacterial keratitis (BK), are notorious for causing rapidly
fulminant disease and permanent vision loss, even among treated patients. In the last sixty …

The eye is innervated by neurons derived from both the central nervous system and
peripheral nervous system (PNS). While much is known about retinal neurobiology and …

Since the last century, advances in healthcare, housing, and education have led to an
increase in life expectancy. Longevity is accompanied by a higher prevalence of age-related …

Pseudomonas aeruginosa is a major cause of blindness and visual impairment in the United
States and worldwide. Using a murine model of keratitis in which abraded corneas are …

Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that primarily infects
epithelial cells of the orofacial mucosa. After initial lytic replication, HSV-1 enters sensory …