Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells.
Dynein has critical roles both in interphase and during cell division. Here, we focus on …

Organisms with closed or open mitosis have differentially evolved various gamma-tubulin
complex (γ-TuC) recruiting factors to organize diverse cellular microtubule (MT) arrays …

Majewski osteodysplastic primordial dwarfism type II (MOPDII) is caused by mutations in the
centrosome gene pericentrin (PCNT) that lead to severe pre-and postnatal growth …

Numerical centrosome aberrations underlie certain developmental abnormalities and may
promote cancer. A cell maintains normal centrosome numbers by coupling centrosome …

The microtubule motor dynein plays a key role in cellular organization. However, little is
known about how dynein's biosynthesis, assembly, and functional diversity are orchestrated …

Mammalian centrosomes and cilia play key roles in many cellular processes and their
deregulation is linked to cancer and ciliopathies. Spatiotemporal regulation of their …

Background & Aims Hepatitis B virus (HBV) has a DNA genome but replicates within the
nucleus by reverse transcription of an RNA pregenome, which is converted to DNA in …

The major microtubule-organizing center (MTOC) in animal cells, the centrosome, comprises
a pair of centrioles surrounded by pericentriolar material (PCM), which nucleates and …

Noncentrosomal microtubule (MT) nucleation at the Golgi generates MT network asymmetry
in motile vertebrate cells. Investigating the Golgi-derived MT (GDMT) distribution, we find …

The centrosome, which consists of centrioles and pericentriolar material (PCM), becomes
mature and assembles mitotic spindles by increasing the number of microtubules (MTs) …