Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …

In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded
considerably. Key observations have challenged the traditional definition of Treg cells and …

B cells, which are critical for intestinal homeostasis, remain understudied in ulcerative colitis
(UC). In this study, we recruited three cohorts of patients with UC (primary cohort, n= 145; …

Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset of
patients. Here, we applied single-cell technologies to iCD lesions to address whether …

Abstract The FOXP3+ CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …

Immune tolerance is maintained in lymphoid organs (LOs). Despite the presence of complex
immune cell networks in non-LOs, it is unknown whether self-tolerance is maintained in …

Regulatory T cells (Treg cells) are key players in ensuring a peaceful coexistence with
microorganisms and food antigens at intestinal borders. Startling new information has …

Regulatory T (Treg) cells suppress effective antitumor immunity in tumor-bearing hosts,
thereby becoming promising targets in cancer immunotherapy. Despite the importance of …

Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a
requisite role in the maintenance of immunological homeostasis and prevention of …

Immune check point blockade therapy has revolutionized the standard of cancer treatment
and is credited with producing remarkable tumor remissions and increase in overall survival …