[HTML][HTML] Innovative drying technologies for biopharmaceuticals
In the past two decades, biopharmaceuticals have been a breakthrough in improving the
quality of lives of patients with various cancers, autoimmune, genetic disorders etc. With the …
quality of lives of patients with various cancers, autoimmune, genetic disorders etc. With the …
Protein‐based Nanoparticles: from Drug Delivery to Imaging, Nanocatalysis and Protein Therapy
J Kaltbeitzel, PR Wich - Angewandte Chemie International …, 2023 - Wiley Online Library
Proteins and enzymes are versatile biomaterials for a wide range of medical applications
due to their high specificity for receptors and substrates, high degradability, low toxicity, and …
due to their high specificity for receptors and substrates, high degradability, low toxicity, and …
Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems
The global pharmaceutical market has recently shifted its focus from small molecule drugs to
peptide, protein, and nucleic acid drugs, which now comprise a majority of the top-selling …
peptide, protein, and nucleic acid drugs, which now comprise a majority of the top-selling …
[HTML][HTML] Stabilizing vaccines via drying: Quality by design considerations
Z Ghaemmaghamian, R Zarghami, G Walker… - Advanced Drug Delivery …, 2022 - Elsevier
Pandemics and epidemics are continually challenging human beings' health and imposing
major stresses on the societies particularly over the last few decades, when their frequency …
major stresses on the societies particularly over the last few decades, when their frequency …
[HTML][HTML] Production of biopharmaceutical dried-powders using supercritical CO2 technology
The inability of many biopharmaceutical formulations to retain their structure and integrity
when in solution represents a major issue for their transport and storage, reducing their shelf …
when in solution represents a major issue for their transport and storage, reducing their shelf …
Spray freeze drying of biologics: a review and applications for inhalation delivery
S Farinha, JV Sá, PR Lino, M Galésio, J Pires… - Pharmaceutical …, 2023 - Springer
Biopharmaceuticals have established an indisputable presence in the pharmaceutical
pipeline, enabling highly specific new therapies. However, manufacturing, isolating, and …
pipeline, enabling highly specific new therapies. However, manufacturing, isolating, and …
Long-acting injectable formulation technologies: challenges and opportunities for the delivery of fragile molecules
A Gonella, S Grizot, F Liu… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction The development of long-acting injectables (LAIs) for protein and peptide
therapeutics has been a key challenge over the last 20 years. If these molecules offer …
therapeutics has been a key challenge over the last 20 years. If these molecules offer …
Encapsulation of bioactive peptides by spray-drying and electrospraying
C Berraquero-García, R Pérez-Gálvez… - Foods, 2023 - mdpi.com
Bioactive peptides derived from enzymatic hydrolysis are gaining attention for the production
of supplements, pharmaceutical compounds, and functional foods. However, their inclusion …
of supplements, pharmaceutical compounds, and functional foods. However, their inclusion …
Spray-dried and spray-freeze-dried powder formulations of an anti-interleukin-4Rα antibody for pulmonary delivery
HW Pan, HC Seow, JCK Lo, J Guo, L Zhu… - Pharmaceutical …, 2022 - Springer
Objective The therapeutic options for severe asthma are limited, and the biological therapies
are all parenterally administered. The purpose of this study was to formulate a monoclonal …
are all parenterally administered. The purpose of this study was to formulate a monoclonal …
Recent progress in drying technologies for improving the stability and delivery efficiency of biopharmaceuticals
F Emami, M Keihan Shokooh… - Journal of Pharmaceutical …, 2023 - Springer
Background Most biopharmaceuticals are developed in liquid dosage forms that are less
stable than solid forms. To ensure the stability of biopharmaceuticals, it is critical to use an …
stable than solid forms. To ensure the stability of biopharmaceuticals, it is critical to use an …