[HTML][HTML] Innovative drying technologies for biopharmaceuticals

A Sharma, D Khamar, S Cullen, A Hayden… - International Journal of …, 2021 - Elsevier
In the past two decades, biopharmaceuticals have been a breakthrough in improving the
quality of lives of patients with various cancers, autoimmune, genetic disorders etc. With the …

Protein‐based Nanoparticles: from Drug Delivery to Imaging, Nanocatalysis and Protein Therapy

J Kaltbeitzel, PR Wich - Angewandte Chemie International …, 2023 - Wiley Online Library
Proteins and enzymes are versatile biomaterials for a wide range of medical applications
due to their high specificity for receptors and substrates, high degradability, low toxicity, and …

Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems

M Shi, KJ McHugh - Advanced Drug Delivery Reviews, 2023 - Elsevier
The global pharmaceutical market has recently shifted its focus from small molecule drugs to
peptide, protein, and nucleic acid drugs, which now comprise a majority of the top-selling …

[HTML][HTML] Stabilizing vaccines via drying: Quality by design considerations

Z Ghaemmaghamian, R Zarghami, G Walker… - Advanced Drug Delivery …, 2022 - Elsevier
Pandemics and epidemics are continually challenging human beings' health and imposing
major stresses on the societies particularly over the last few decades, when their frequency …

[HTML][HTML] Production of biopharmaceutical dried-powders using supercritical CO2 technology

A O'Sullivan, KM Ryan, L Padrela - The Journal of Supercritical Fluids, 2022 - Elsevier
The inability of many biopharmaceutical formulations to retain their structure and integrity
when in solution represents a major issue for their transport and storage, reducing their shelf …

Spray freeze drying of biologics: a review and applications for inhalation delivery

S Farinha, JV Sá, PR Lino, M Galésio, J Pires… - Pharmaceutical …, 2023 - Springer
Biopharmaceuticals have established an indisputable presence in the pharmaceutical
pipeline, enabling highly specific new therapies. However, manufacturing, isolating, and …

Long-acting injectable formulation technologies: challenges and opportunities for the delivery of fragile molecules

A Gonella, S Grizot, F Liu… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction The development of long-acting injectables (LAIs) for protein and peptide
therapeutics has been a key challenge over the last 20 years. If these molecules offer …

Encapsulation of bioactive peptides by spray-drying and electrospraying

C Berraquero-García, R Pérez-Gálvez… - Foods, 2023 - mdpi.com
Bioactive peptides derived from enzymatic hydrolysis are gaining attention for the production
of supplements, pharmaceutical compounds, and functional foods. However, their inclusion …

Spray-dried and spray-freeze-dried powder formulations of an anti-interleukin-4Rα antibody for pulmonary delivery

HW Pan, HC Seow, JCK Lo, J Guo, L Zhu… - Pharmaceutical …, 2022 - Springer
Objective The therapeutic options for severe asthma are limited, and the biological therapies
are all parenterally administered. The purpose of this study was to formulate a monoclonal …

Recent progress in drying technologies for improving the stability and delivery efficiency of biopharmaceuticals

F Emami, M Keihan Shokooh… - Journal of Pharmaceutical …, 2023 - Springer
Background Most biopharmaceuticals are developed in liquid dosage forms that are less
stable than solid forms. To ensure the stability of biopharmaceuticals, it is critical to use an …