Matrix metalloproteinase inhibitors in cancer therapy: turning past failures into future successes
A Winer, S Adams, P Mignatti - Molecular cancer therapeutics, 2018 - AACR
The matrix metalloproteinases (MMP) are a family of proteolytic enzymes that degrade
multiple components of the extracellular matrix. A large body of experimental and clinical …
multiple components of the extracellular matrix. A large body of experimental and clinical …
TIMPs: versatile extracellular regulators in cancer
HW Jackson, V Defamie, P Waterhouse… - Nature Reviews …, 2017 - nature.com
A compelling long-term goal of cancer biology is to understand the crucial players during
tumorigenesis in order to develop new interventions. Here, we review how the four non …
tumorigenesis in order to develop new interventions. Here, we review how the four non …
Passing the vascular barrier: endothelial signaling processes controlling extravasation
N Wettschureck, B Strilic… - Physiological …, 2019 - journals.physiology.org
A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …
Concise review: MSC adhesion cascade—insights into homing and transendothelial migration
F Nitzsche, C Müller, B Lukomska, J Jolkkonen… - Stem …, 2017 - academic.oup.com
Mesenchymal stem cells (MSCs) are promising candidates for adult cell therapies in
regenerative medicine. To fully exert their potential, efficient homing and migration toward …
regenerative medicine. To fully exert their potential, efficient homing and migration toward …
Metastasis and MAPK pathways
M Kciuk, A Gielecińska, A Budzinska… - International journal of …, 2022 - mdpi.com
Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is
limited due to the metastasis of cells to distant locations of the body through the blood and …
limited due to the metastasis of cells to distant locations of the body through the blood and …
Mesenchymal stem cell homing to improve therapeutic efficacy in liver disease
M Yuan, X Hu, L Yao, Y Jiang, L Li - Stem Cell Research & Therapy, 2022 - Springer
Mesenchymal stem cell (MSC) transplantation, as an alternative strategy to orthotopic liver
transplantation, has been evaluated for treating end-stage liver disease. Although the …
transplantation, has been evaluated for treating end-stage liver disease. Although the …
The impact of matrix metalloproteinase-9 on the sequential steps of the metastatic process
G Barillari - International journal of molecular sciences, 2020 - mdpi.com
In industrialized countries, cancer is the second leading cause of death after cardiovascular
disease. Most cancer patients die because of metastases, which consist of the self …
disease. Most cancer patients die because of metastases, which consist of the self …
The role of mesenchymal stem cells in radiation-induced lung fibrosis
Radiation therapy is one of the most important treatment modalities for thoracic tumors.
Despite significant advances in radiation techniques, radiation-induced lung injury (RILI) still …
Despite significant advances in radiation techniques, radiation-induced lung injury (RILI) still …
[HTML][HTML] Extracellular vesicle-mediated transport: Reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis
D Brena, MB Huang, V Bond - Translational oncology, 2022 - Elsevier
Breast cancer metastatic progression to critical secondary sites is the second leading cause
of cancer-related mortality in women. While existing therapies are highly effective in …
of cancer-related mortality in women. While existing therapies are highly effective in …
[HTML][HTML] Roles of NGAL and MMP-9 in the tumor microenvironment and sensitivity to targeted therapy
S Candido, SL Abrams, LS Steelman… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Various, diverse molecules contribute to the tumor microenvironment and influence invasion
and metastasis. In this review, the roles of neutrophil gelatinase-associated lipocalin (NGAL) …
and metastasis. In this review, the roles of neutrophil gelatinase-associated lipocalin (NGAL) …