Introduction An estimated 30,000 children develop multidrug-resistant (MDR) tuberculosis
(TB) each year, with only a small proportion diagnosed and treated. This field has historically …

The aim of this operational handbook is to provide practical guidance on the implementation
of the World Health Organization (WHO) policy recommendations on the prevention and …

Optimal diagnosis and management of children aged< 15 y with rifampicin-or multidrug-
resistant tuberculosis (RR/MDR-TB) relies on identification of adults with the disease and …

Background Estimates suggest that at least 30 000 children develop multidrug-resistant or
rifampicin-resistant tuberculosis each year. Despite household contact management (HCM) …

Abstract In Karachi, Pakistan, a South Asian megacity with a high prevalence of tuberculosis
(TB) and low HIV prevalence, we assessed the effectiveness of fluoroquinolone-based …

Background Contacts of patients with multidrug-resistant tuberculosis (MDR-TB) are at risk
of developing TB disease. Tuberculosis preventive treatment (TPT) is an intervention that …

Introduction According to the latest report from the World Health Organization (WHO),
approximately 10.0 million people fell ill with tuberculosis (TB) in 2020, 12% of which were …

Background The use of systems engineering tools, including the development and use of
care cascades using routinely collected data, process mapping, and continuous quality …

Background To ensure patient-centered tuberculosis preventive treatment, it is important to
consider factors that make it easier for patients to complete treatment. However, there is little …

Background Several clinical trials of tuberculosis preventive treatment (TPT) for household
contacts of patients with multidrug-or rifampin-resistant tuberculosis (MDR/RR-TB) are …