The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes
accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of …

During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome
stability by delaying cell division until accurate chromosome segregation can be …

Although the nuclear pore complex (NPC) is best known for its primary function as the key
regulator of molecular traffic between the cytoplasm and the nucleus, a growing body of …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Spindle assembly required during mitosis depends on microtubule polymerization. We
demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes …

In the cytosol, actin polymers, intermediate filaments and microtubules can anchor to cell
surface adhesions and interlink to form intricate networks. This cytoskeleton is anchored to …

Error-free chromosome segregation relies on stable connections between kinetochores and
spindle microtubules. The spindle assembly checkpoint (SAC) monitors such connections …

Nuclear pore complexes (NPCs) are composed of several copies of∼ 30 different proteins
called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the …

The mitotic spindle accurately segregates genetic instructions by moving chromosomes to
spindle poles (anaphase A) and separating the poles (anaphase B) so that, in general, the …

The spindle assembly checkpoint (SAC) delays anaphase until all chromosomes are
bioriented on the mitotic spindle. Under current models, unattached kinetochores transduce …