STAT3, stem cells, cancer stem cells and p63
M Galoczova, P Coates, B Vojtesek - Cellular & molecular biology letters, 2018 - Springer
Abstract Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor
with many important functions in the biology of normal and transformed cells. Its regulation is …
with many important functions in the biology of normal and transformed cells. Its regulation is …
Potential anticancer properties and mechanisms of action of curcumin
NG Vallianou, A Evangelopoulos, N Schizas… - Anticancer …, 2015 - ar.iiarjournals.org
Curcumin, a yellow substance belonging to the polyphenols superfamily, is the active
component of turmeric, a common Indian spice, which is derived from the dried rhizome of …
component of turmeric, a common Indian spice, which is derived from the dried rhizome of …
[HTML][HTML] Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer
S Ouyang, H Li, L Lou, Q Huang, Z Zhang, J Mo, M Li… - Redox biology, 2022 - Elsevier
Chemotherapy is still one of the principal treatments for gastric cancer, but the clinical
application of 5-FU is limited by drug resistance. Here, we demonstrate that ferroptosis …
application of 5-FU is limited by drug resistance. Here, we demonstrate that ferroptosis …
Cancer stem cell hierarchy in glioblastoma multiforme
A Bradshaw, A Wickremsekera, ST Tan, L Peng… - Frontiers in …, 2016 - frontiersin.org
Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …
The STATs of cancer—new molecular targets come of age
H Yu, R Jove - Nature Reviews Cancer, 2004 - nature.com
Tumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain
angiogenesis and evade immune surveillance. STAT proteins—especially STAT3 and …
angiogenesis and evade immune surveillance. STAT proteins—especially STAT3 and …
Age-associated chronic diseases require age-old medicine: role of chronic inflammation
S Prasad, B Sung, BB Aggarwal - Preventive medicine, 2012 - Elsevier
Most chronic diseases—such as cancer, cardiovascular disease (CVD), Alzheimer disease,
Parkinson disease, arthritis, diabetes and obesity—are becoming leading causes of …
Parkinson disease, arthritis, diabetes and obesity—are becoming leading causes of …
STAT3 in the systemic inflammation of cancer cachexia
Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
K Siddiquee, S Zhang, WC Guida… - Proceedings of the …, 2007 - National Acad Sciences
S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified
from the National Cancer Institute chemical libraries by using structure-based virtual …
from the National Cancer Institute chemical libraries by using structure-based virtual …
JAK-STAT signaling in cancer: From cytokines to non-coding genome
In the past decades, studies of the Janus kinases (JAKs) and signal transducers and
activators of transcription (STATs) signaling have uncovered highly conserved programs …
activators of transcription (STATs) signaling have uncovered highly conserved programs …
JAK‐STAT core cancer pathway: an integrative cancer interactome analysis
Through a comprehensive review and in silico analysis of reported data on STAT‐linked
diseases, we analysed the communication pathways and interactome of the seven STATs in …
diseases, we analysed the communication pathways and interactome of the seven STATs in …