Role of neuroinflammation in neurodegeneration development

W Zhang, D Xiao, Q Mao, H Xia - Signal transduction and targeted …, 2023 - nature.com
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions

X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - Signal transduction and …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

Neuroinflammation in Parkinson's disease–putative pathomechanisms and targets for disease-modification

A Grotemeyer, RL McFleder, J Wu… - Frontiers in …, 2022 - frontiersin.org
Parkinson's disease (PD) is a progressive and debilitating chronic disease that affects more
than six million people worldwide, with rising prevalence. The hallmarks of PD are motor …

The systemic immune response in Parkinson's disease: Focus on the peripheral immune component

J Lauritsen, M Romero-Ramos - Trends in neurosciences, 2023 - cell.com
During Parkinson's disease (PD), both the central nervous system (CNS) and peripheral
nervous system (PNS) are affected. In parallel, innate immune cells respond early to …

DAT and TH expression marks human Parkinson's disease in peripheral immune cells

A Gopinath, P Mackie, B Hashimi, AM Buchanan… - npj Parkinson's …, 2022 - nature.com
Parkinson's disease (PD) is marked by a loss of dopamine neurons, decreased dopamine
transporter (DAT) and tyrosine hydroxylase (TH) expression. However, this validation …

Role of α-synuclein in microglia: Autophagy and phagocytosis balance neuroinflammation in Parkinson's disease

QK Lv, KX Tao, XB Wang, XY Yao, MZ Pang… - Inflammation …, 2023 - Springer
Background Parkinson's disease (PD) is the second most common neurodegenerative
disease, and is characterized by accumulation of α-synuclein (α-syn). Neuroinflammation …

The immune system in Parkinson's disease: what we know so far

C Roodveldt, L Bernardino, O Oztop-Cakmak, M Dragic… - Brain, 2024 - academic.oup.com
Parkinson's disease is characterized neuropathologically by the degeneration of
dopaminergic neurons in the ventral midbrain, the accumulation of α-synuclein (α-syn) …

Regulation of pain perception by microbiota in Parkinson disease

Z Manjarres, M Calvo, R Pacheco… - Pharmacological …, 2024 - Elsevier
Pain perception involves current stimulation in peripheral nociceptive nerves and the
subsequent stimulation of postsynaptic excitatory neurons in the spinal cord. Importantly, in …

[HTML][HTML] Impact of sex on neuroimmune contributions to Parkinson's disease

M Bourque, M Morissette, D Soulet, T Di Paolo - Brain Research Bulletin, 2023 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease. Inflammation has been observed in both the idiopathic and familial …

[HTML][HTML] The role of antiviral CD8+ T cells in cognitive impairment

KL Reagin, KE Funk - Current opinion in neurobiology, 2022 - Elsevier
The impact of the immune system on the etiopathogenesis of neurodegenerative diseases,
including Alzheimer's disease, is a rapidly growing area of investigation. Evidence from …