For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …

Sodium/glucose cotransporter 2 (SGLT2) inhibitors exert important renoprotective effects in
the diabetic kidney, which cannot be readily explained by their actions to lower blood …

Diabetic nephropathy (DN), the leading cause of end-stage renal disease, is the most
significant microvascular complication of diabetes and poses a severe public health concern …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide.
Exosomes (Exo) derived from human umbilical cord mesenchymal stem cells (HUC-MSCs) …

Growing evidence indicates that oxidative and endoplasmic reticular stress, which trigger
changes in ion channels and inflammatory pathways that may undermine cellular …

Obstructive nephropathy favors the progression to chronic kidney disease (CKD), a severe
health problem worldwide. The unilateral ureteral obstruction (UUO) model is used to study …

The use of gentamicin (GM) is limited due to its nephrotoxicity mediated by oxidative stress.
This study aimed to evaluate the capacity of a flavonoid-rich extract of Sambucus nigra L …

Organelle damage can cause various kidney diseases. In particular, organelle stress such
as decreased proteostatic activity in the endoplasmic reticulum (ER) and altered energy …

Aging is an independent risk factor for acute kidney injury and subsequent chronic kidney
diseases, while the underlying mechanism is still elusive. Here, we found that renal tubules …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected syndromes
that represent a global public health challenge. Organelles play essential roles in a vast …