Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

Highlights•Dementia involves the chronic and progressive deterioration of cognitive
functions.•Alzheimer's disease is the most common form of dementia.•Abnormally …

Abundant filamentous inclusions of tau are characteristic of more than 20
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …

A defining pathological feature of most neurodegenerative diseases is the assembly of
proteins into amyloid that form disease-specific structures. In Alzheimer's disease, this is …

The use of transgenic mice displaying amyloid-β (Aβ) brain pathology has been essential for
the preclinical assessment of new treatment strategies for Alzheimer's disease. However, the …

Background Mouse models that overexpress human mutant Tau (P301S and P301L) are
commonly used in preclinical studies of Alzheimer's Disease (AD) and while several drugs …

Increased tau acetylation at K274 and K281 has been observed in the brains of Alzheimer's
disease (AD) patients and animal models, and mitochondrial dysfunction are noticeable and …

The microtubule-associated protein tau is an intrinsically disordered protein containing a few
short and transient secondary structures. Tau physiologically associates with microtubules …

Intra-or extracellular aggregates of proteins are central pathogenic features in most
neurodegenerative disorders. The accumulation of such proteins in diseased brains is …

Alzheimer's disease (AD) is a severe, growing, multifactorial disorder affecting millions of
people worldwide characterized by cognitive decline and neurodegeneration. The …